The Collaborative Cross, developing a resource for mammalian systems genetics: A status report of the Wellcome Trust cohort

Fuad A. Iraqi, Gary Churchill, Richard Mott

Research output: Contribution to journalComment/debate

104 Scopus citations

Abstract

We report on the progress of a project funded by the Wellcome Trust to produce over 100 recombinant inbred mouse lines as part of the Collaborative Cross (CC) genetic reference panel. These new strains of mice are being derived from a set of eight genetically diverse founders. The genomes of the finished strains will be mosaics of the founder strains' genomes with a high density of independent recombination breakpoints. The CC mice will be available for distribution free of any intellectual property constraints to serve as a community resource for systems genetics studies.

Original languageEnglish
Pages (from-to)379-381
Number of pages3
JournalMammalian Genome
Volume19
Issue number6
DOIs
StatePublished - Jun 2008

Funding

FundersFunder number
National Institutes of Health
U.S. Department of Energy
Oak Ridge National Laboratory
Lawrence Ellison Foundation
Wellcome Trust
Tel Aviv University
International Livestock Research Institute

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