TY - JOUR
T1 - The Clinical Significance of Extreme Leukocytosis among Newborns
T2 - A Retrospective Cohort Study
AU - Golomb, Oryan
AU - Schushan-Eisen, Irit
AU - Maayan-Metzger, Ayala
AU - Elisha, Naama
AU - Strauss, Tzipora
AU - Mazkereth, Ram
N1 - Publisher Copyright:
© 2024 Thieme Medical Publishers, Inc.. All rights reserved.
PY - 2024/5/22
Y1 - 2024/5/22
N2 - Objective ?The aim of the study is to examine the clinical significance of extreme leukocytosis (>40,000 cells/μL) at birth among neonates. Study Design ?Data were retrospectively collected on 208 infants with leukocytosis >40,000 cells/μL and on matched normal controls as determined in complete blood counts obtained on the first day of life. Results ?There were no significant group differences in birth weight, Apgar's score, timing of respiratory support, hospitalization in special care units or rehospitalization during the first month of life. All neonates with leukocytosis received antibiotics. The blood cultures of both groups were negative. A multivariate analysis showed that leukocytosis did not predict either the presence of symptoms associated with sepsis among neonates or hospitalization in a neonatal special care unit. Conclusion ?Extreme leukocytosis on the first day of life is a poor predictor of infection. Clinicians should decide upon treatment according to risk factors and symptoms but not according to the degree of leukocytosis. Key Points Extreme leukocytosis on the first day of life is a poor predictor of infection. Clinicians should decide upon treatment according to risk factors and symptoms. Leukocytosis was not predictive of a higher risk of morbidity in neonates.
AB - Objective ?The aim of the study is to examine the clinical significance of extreme leukocytosis (>40,000 cells/μL) at birth among neonates. Study Design ?Data were retrospectively collected on 208 infants with leukocytosis >40,000 cells/μL and on matched normal controls as determined in complete blood counts obtained on the first day of life. Results ?There were no significant group differences in birth weight, Apgar's score, timing of respiratory support, hospitalization in special care units or rehospitalization during the first month of life. All neonates with leukocytosis received antibiotics. The blood cultures of both groups were negative. A multivariate analysis showed that leukocytosis did not predict either the presence of symptoms associated with sepsis among neonates or hospitalization in a neonatal special care unit. Conclusion ?Extreme leukocytosis on the first day of life is a poor predictor of infection. Clinicians should decide upon treatment according to risk factors and symptoms but not according to the degree of leukocytosis. Key Points Extreme leukocytosis on the first day of life is a poor predictor of infection. Clinicians should decide upon treatment according to risk factors and symptoms. Leukocytosis was not predictive of a higher risk of morbidity in neonates.
KW - antibiotic treatment
KW - blood culture
KW - complete blood count
KW - leukocytosis
KW - neonatal sepsis
UR - http://www.scopus.com/inward/record.url?scp=85135738981&partnerID=8YFLogxK
U2 - 10.1055/a-1906-9048
DO - 10.1055/a-1906-9048
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C2 - 35863372
AN - SCOPUS:85135738981
SN - 0735-1631
VL - 41
SP - E470-E476
JO - American Journal of Perinatology
JF - American Journal of Perinatology
ER -