The Clinical Impact of Camera-Based Positron Emission Tomography Imaging in Patients with Recurrent Colorectal Cancer

Elka Miller, Hedva Lerman, Mordechai Gutman, Arie Figer, Genady Livshitz, Einat Even-Sapir*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Rationale and Objectives: F18-fluorodeoxyglucose (FDG)-positron emission tomography (PET) studies have clinical value in suspected recurrent or metastatic colorectal cancer cases. Because this modality is not accessible for many patients, a camera-based FDG (CB-FDG) coincidence imaging was suggested as an alternative. Although inferior in resolution to a dedicated PET system, it can make FDG studies available to more patients. We assessed the clinical value of CB-FDG in patients with recurrent colorectal cancer. Methods: The disease stage and treatment approach in 83 patients were twice determined by an oncologist and a surgeon, first based on the patient's records and blind to CB-FDG findings and then with the inclusion of FDG results in the decision-making analysis. Results: On a lesion-based analysis, the sensitivity of CB-FDG was 95% and the specificity was 81% compared with 88% and 64%, respectively, for computed tomography. Adding FDG findings led to disease-stage alteration in 47 patients (57%), upstaging in 35 (42%), and downstaging in 12 (15%). FDG localized the tumor sites in 21 of 26 patients (81%) with suspected clinical recurrence and a negative conventional imaging workup. In 8 patients, FDG ruled out viable tumor tissue suggested by other modalities. The oncologist's suggested treatment approach was altered in 54% of the patients and the surgeon altered the decision on operability in 28%. Conclusion: CB-FDG assessment has clinical value for both staging and selecting treatment in patients with recurrent colorectal cancer and can be considered an alternative to an nonaccessible dedicated PET system.

Original languageEnglish
Pages (from-to)8-12
Number of pages5
JournalInvestigative Radiology
Issue number1
StatePublished - Jan 2004


  • Colorectal cancer
  • FDG
  • Gamma camera
  • PET


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