TY - JOUR
T1 - The Clinical Characteristics of Unilateral Placoid Pigment Epitheliopathies
AU - Kutluturk, Isil
AU - Agarwal, Aniruddha
AU - Shulman, Shiri
AU - Vitale, Albert
AU - Parodi, Maurizio B.
AU - Conrady, Christoph D.
AU - Hurtikova, Katarina
AU - Cunha Souza, Eduardo
AU - Rodriguez, Ever Caso
AU - Chhablani, Jay
AU - Tappeiner, Christoph
AU - Gerding, Heinrich
AU - Zinkernagel, Martin S.
AU - Tucker, William
AU - Munk, Marion R.
N1 - Publisher Copyright:
© 2022 Taylor & Francis Group, LLC.
PY - 2021
Y1 - 2021
N2 - Purpose: Placoid-pigment-epitheliopathies like Acute-Posterior-Multifocal-Placoid-Pigment Epitheliopathy (APMPPE) and Relentless-Placoid-Choroidopathy (RPC) usually show bilateral involvement. This retrospective case series describes the clinical features with unilateral disease onset. Methods: 21 patients from 9 tertiary referring institutions were collected and evaluated. Results: Seventeen patients were included: 11 (65%) had unilateral placoid-pigment-epitheliopathy consistent with APMPPE, 6 (35%) with RPC (mean age: 28.82 ± 9.1 years). Mean follow-up time was 45 ± 48 months. Forty-one percent fellow-eyes had initial inflammatory signs including vitreous-cells, vascular-sheathing, and ONH swelling. Thirty-five percent developed chorioretinal lesions during follow-up after 19.5 ± 16.9 months. Initial inflammation in fellow-eye was not associated with fellow-eye involvement (p =.5). However, subfoveal choroidal-thickness (SCT) at baseline was significantly thicker in fellow-eyes who developed chorioretinal lesion compared to fellow-eyes who did not (400 ± 70 µm versus 283 ± 127 µm,p =.047). Conclusion: Unaffected fellow-eyes may have inflammatory signs at initial disease-onset and may develop lesions over time. They should be carefully monitored, particularly if they present with an increased SCT.
AB - Purpose: Placoid-pigment-epitheliopathies like Acute-Posterior-Multifocal-Placoid-Pigment Epitheliopathy (APMPPE) and Relentless-Placoid-Choroidopathy (RPC) usually show bilateral involvement. This retrospective case series describes the clinical features with unilateral disease onset. Methods: 21 patients from 9 tertiary referring institutions were collected and evaluated. Results: Seventeen patients were included: 11 (65%) had unilateral placoid-pigment-epitheliopathy consistent with APMPPE, 6 (35%) with RPC (mean age: 28.82 ± 9.1 years). Mean follow-up time was 45 ± 48 months. Forty-one percent fellow-eyes had initial inflammatory signs including vitreous-cells, vascular-sheathing, and ONH swelling. Thirty-five percent developed chorioretinal lesions during follow-up after 19.5 ± 16.9 months. Initial inflammation in fellow-eye was not associated with fellow-eye involvement (p =.5). However, subfoveal choroidal-thickness (SCT) at baseline was significantly thicker in fellow-eyes who developed chorioretinal lesion compared to fellow-eyes who did not (400 ± 70 µm versus 283 ± 127 µm,p =.047). Conclusion: Unaffected fellow-eyes may have inflammatory signs at initial disease-onset and may develop lesions over time. They should be carefully monitored, particularly if they present with an increased SCT.
KW - Choroiditis
KW - choroidopathy
KW - inflammation
KW - placoid
KW - relentless
UR - http://www.scopus.com/inward/record.url?scp=85079756387&partnerID=8YFLogxK
U2 - 10.1080/09273948.2019.1705498
DO - 10.1080/09273948.2019.1705498
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C2 - 32077774
AN - SCOPUS:85079756387
VL - 29
SP - 1072
EP - 1079
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
SN - 0927-3948
IS - 6
ER -