The cis side of juxtacrine signaling: A new role in the development of the nervous system

Avraham Yaron*, David Sprinzak

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Cell-cell communication by juxtacrine signaling plays a key role in the development of the nervous system, from cell fate determination through axonal guidance to synaptogenesis. Interestingly, several juxtacrine signaling systems exhibit an inhibitory interaction between receptors and ligands in the same cell, termed . cis inhibition. These include the Notch, semaphorin and ephrin signaling systems. Here we review the role of . cis inhibition in these signaling systems in the development of the nervous system. We compare and contrast . cis inhibition mechanisms and discuss their potential cellular function as a threshold-generating mechanism. The prevalence of . cis inhibition suggests that these interactions and their functional regulatory roles may serve as a general design principle for juxtacrine signaling-mediated processes during and beyond neurodevelopment.

Original languageEnglish
Pages (from-to)230-239
Number of pages10
JournalTrends in Neurosciences
Volume35
Issue number4
DOIs
StatePublished - Apr 2012

Funding

FundersFunder number
Marla Schaefer
Human Frontier Science Program
Israel Science Foundation

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