TY - JOUR
T1 - The cis side of juxtacrine signaling
T2 - A new role in the development of the nervous system
AU - Yaron, Avraham
AU - Sprinzak, David
N1 - Funding Information:
We would like to thank Oren Schuldiner, Avigdor Eldar and Iftach Nachman for their insightful comments on the manuscript. A Human Frontier Science Program (HFSP) Career Development Award, a grant from Marla Schaefer and the Israel Science Foundation supported research related to this review in the laboratory of A.Y. A Marie Curie reintegration grant and the Israel Science Foundation supported research related to this review in the laboratory of D.S.
PY - 2012/4
Y1 - 2012/4
N2 - Cell-cell communication by juxtacrine signaling plays a key role in the development of the nervous system, from cell fate determination through axonal guidance to synaptogenesis. Interestingly, several juxtacrine signaling systems exhibit an inhibitory interaction between receptors and ligands in the same cell, termed . cis inhibition. These include the Notch, semaphorin and ephrin signaling systems. Here we review the role of . cis inhibition in these signaling systems in the development of the nervous system. We compare and contrast . cis inhibition mechanisms and discuss their potential cellular function as a threshold-generating mechanism. The prevalence of . cis inhibition suggests that these interactions and their functional regulatory roles may serve as a general design principle for juxtacrine signaling-mediated processes during and beyond neurodevelopment.
AB - Cell-cell communication by juxtacrine signaling plays a key role in the development of the nervous system, from cell fate determination through axonal guidance to synaptogenesis. Interestingly, several juxtacrine signaling systems exhibit an inhibitory interaction between receptors and ligands in the same cell, termed . cis inhibition. These include the Notch, semaphorin and ephrin signaling systems. Here we review the role of . cis inhibition in these signaling systems in the development of the nervous system. We compare and contrast . cis inhibition mechanisms and discuss their potential cellular function as a threshold-generating mechanism. The prevalence of . cis inhibition suggests that these interactions and their functional regulatory roles may serve as a general design principle for juxtacrine signaling-mediated processes during and beyond neurodevelopment.
UR - http://www.scopus.com/inward/record.url?scp=84859270687&partnerID=8YFLogxK
U2 - 10.1016/j.tins.2011.12.003
DO - 10.1016/j.tins.2011.12.003
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C2 - 22222351
AN - SCOPUS:84859270687
SN - 0166-2236
VL - 35
SP - 230
EP - 239
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 4
ER -