TY - JOUR
T1 - The chick as a model for malignant hyperpyrexia
AU - Korczyn, A. D.
AU - Shavit, S.
AU - Shlosberg, I.
PY - 1980/1/25
Y1 - 1980/1/25
N2 - Administration of succinylcholine (SCh) to chicks produces rigid paralysis and death due to respiratory impairment. The mechanism of the SCh effect is probably related to the multiple innervation of muscle fibres, leading to excessive intracellular accumulation of calcium. This situation may be similar to that in malignant hyperpyerxia (MH) occurring in mammals. Dantrolene sodium, phenytoin and procain, drugs used against MH, were found to afford protection against SCh rigidity and death in chicks. It is suggested that the chick can be used as a convenient model for a rapid screening of drugs potentially active against MH.
AB - Administration of succinylcholine (SCh) to chicks produces rigid paralysis and death due to respiratory impairment. The mechanism of the SCh effect is probably related to the multiple innervation of muscle fibres, leading to excessive intracellular accumulation of calcium. This situation may be similar to that in malignant hyperpyerxia (MH) occurring in mammals. Dantrolene sodium, phenytoin and procain, drugs used against MH, were found to afford protection against SCh rigidity and death in chicks. It is suggested that the chick can be used as a convenient model for a rapid screening of drugs potentially active against MH.
KW - Dantrolene sodium
KW - Malignant hyperpyxia
KW - Phenytoin
KW - Procain
KW - Rigidity
KW - Succinylcholine
UR - http://www.scopus.com/inward/record.url?scp=0018843905&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(80)90163-6
DO - 10.1016/0014-2999(80)90163-6
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AN - SCOPUS:0018843905
SN - 0014-2999
VL - 61
SP - 187
EP - 189
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2
ER -