The chick as a model for malignant hyperpyrexia

A. D. Korczyn, S. Shavit, I. Shlosberg

Research output: Contribution to journalArticlepeer-review

Abstract

Administration of succinylcholine (SCh) to chicks produces rigid paralysis and death due to respiratory impairment. The mechanism of the SCh effect is probably related to the multiple innervation of muscle fibres, leading to excessive intracellular accumulation of calcium. This situation may be similar to that in malignant hyperpyerxia (MH) occurring in mammals. Dantrolene sodium, phenytoin and procain, drugs used against MH, were found to afford protection against SCh rigidity and death in chicks. It is suggested that the chick can be used as a convenient model for a rapid screening of drugs potentially active against MH.

Original languageEnglish
Pages (from-to)187-189
Number of pages3
JournalEuropean Journal of Pharmacology
Volume61
Issue number2
DOIs
StatePublished - 25 Jan 1980

Keywords

  • Dantrolene sodium
  • Malignant hyperpyxia
  • Phenytoin
  • Procain
  • Rigidity
  • Succinylcholine

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