The Cell-Death-Associated Polymer PAR Feeds Forward α-Synuclein Toxicity in Parkinson's Disease

Maya Donyo; Avraham Ashkenazi

doi:10.1016/j.molcel.2018.12.011

The Cell-Death-Associated Polymer PAR Feeds Forward α-Synuclein Toxicity in Parkinson's Disease

Maya Donyo, Avraham Ashkenazi^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

Parkinson's disease (PD) is characterized by protein aggregates of α-synuclein in neurons. In a recent issue of Science, Kam et al. (2018) revealed a feedforward loop in which α-synuclein increases the levels of poly(adenosine 5′-diphosphate-ribose) (PAR) that in turn causes α-synuclein aggregates to be more toxic. This study advances our understanding of PD pathology.

Original language	English
Pages (from-to)	5-6
Number of pages	2
Journal	Molecular Cell
Volume	73
Issue number	1
DOIs	https://doi.org/10.1016/j.molcel.2018.12.011
State	Published - 3 Jan 2019

Funding

Funders	Funder number
Federation of European Biochemical Societies
Azrieli Foundation

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10.1016/j.molcel.2018.12.011

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abstract = "Parkinson's disease (PD) is characterized by protein aggregates of α-synuclein in neurons. In a recent issue of Science, Kam et al. (2018) revealed a feedforward loop in which α-synuclein increases the levels of poly(adenosine 5′-diphosphate-ribose) (PAR) that in turn causes α-synuclein aggregates to be more toxic. This study advances our understanding of PD pathology.",

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The Cell-Death-Associated Polymer PAR Feeds Forward α-Synuclein Toxicity in Parkinson's Disease

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