The Cell-Death-Associated Polymer PAR Feeds Forward α-Synuclein Toxicity in Parkinson's Disease

Maya Donyo, Avraham Ashkenazi*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

Abstract

Parkinson's disease (PD) is characterized by protein aggregates of α-synuclein in neurons. In a recent issue of Science, Kam et al. (2018) revealed a feedforward loop in which α-synuclein increases the levels of poly(adenosine 5′-diphosphate-ribose) (PAR) that in turn causes α-synuclein aggregates to be more toxic. This study advances our understanding of PD pathology.

Original languageEnglish
Pages (from-to)5-6
Number of pages2
JournalMolecular Cell
Volume73
Issue number1
DOIs
StatePublished - 3 Jan 2019

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