The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus

N. Zilberberg, E. Zlotkin, M. Gurevitz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

N. Zilberberg, E. Zlotkin and M. Gurevitz. The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus. Toxicon 29, 1155-1158, 1991.-A 400 nucleotide cDNA clone encoding the depressant insect toxin of the scorpion Buthotus judaicus (BjIT2), was isolated. DNA sequence analysis suggests that the toxin is a processed product of a precursor composed of: (1) a 21 amino acid residue signal peptide; (2) a 61 amino acid region of the mature toxin; and (3) an additional Arg-Lys-Lys tail at the carboxy terminus prior to a termination codon. Comparison between the precursor polypeptides of BjIT2 and another depressant insect toxin derived from the scorpion Leiurus quinquestriatus hebraeus (LqhIT2) shows similarities in their hydropathic profiles.

Original languageEnglish
Pages (from-to)1155-1158
Number of pages4
JournalToxicon
Volume29
Issue number9
DOIs
StatePublished - 1991

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