The cardiovascular benefits of indiscriminate supplementation of omega-3 fatty acids; meta-analysis and decision-making approach

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: The meta-analysis was conducted to estimate of the cardiovascular benefits of indiscriminate supplementation of omega-3 capsules. The results, expressed in terms of quality adjusted life years (QALY) intuitively understood by the general public, can be the basis for the (personal) decision on whether to take omega-3 supplements. Methods: The results of meta-analysis of eight double-blind, placebo-controlled clinical trials are expressed in terms of QALY, using the Markov model and Monte Carlo simulations. Results: Omega-3 supplementation results in a 8% decrease of the risk of cardiac death, unless the patients are treated by statins. Results indicate that omega-3 supplementation may prolong QALY by about a month. Old people gain less, whereas DM-2 patients and people with history of CV events gain more. Discussion: Our analysis yielded an algorithm for estimating benefit from omega-3 supplementation, based on the age and the individual risk of CV events of the patient.

Original languageEnglish
Pages (from-to)549-556
Number of pages8
JournalInternational Journal of Food Sciences and Nutrition
Volume69
Issue number5
DOIs
StatePublished - 4 Jul 2018

Keywords

  • Omega-3 supplementation
  • cardiovascular morbidity and mortality
  • statins

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