TY - JOUR
T1 - The caprine arthritis-encephalitis virus is a distinct virus within the lentivirus group
AU - Gazit, Arnona
AU - Yaniv, Abraham
AU - Dvir, Malca
AU - Perk, Kalman
AU - Irving, Steven G.
AU - Dahlberg, John E.
PY - 1983/1/15
Y1 - 1983/1/15
N2 - The genetic relatedness among viral genomes of caprine arthritis-encephalitis virus, visna virus, and progressive pneumonia virus, was determined. Whereas the genomic RNAS of two strains of visna virus are indistinguishable as reflected both by their annealing kinetics as well as by the thermal stability of the hybrids, the caprine arthritis-encephalitis virus and visna virus have only 30% of their nucleic acid sequences in common. Furthermore, within the homologous regions of the two viral genomes, there is a significant level (∼10%) of mismatched base pairs. This limited homology that exists between caprine arthritis-encephalitis virus and visna virus was lower than the sequence homology observed between the genomes of visna virus and progressive pneumonia virus, or between the genomes of caprine arthritis-encephalitis virus and progressive pneumonia virus. All this indicates that caprine arthritis-encephalitis virus is an additional distinct member of the Lentivirus group of the Retroviridae family.
AB - The genetic relatedness among viral genomes of caprine arthritis-encephalitis virus, visna virus, and progressive pneumonia virus, was determined. Whereas the genomic RNAS of two strains of visna virus are indistinguishable as reflected both by their annealing kinetics as well as by the thermal stability of the hybrids, the caprine arthritis-encephalitis virus and visna virus have only 30% of their nucleic acid sequences in common. Furthermore, within the homologous regions of the two viral genomes, there is a significant level (∼10%) of mismatched base pairs. This limited homology that exists between caprine arthritis-encephalitis virus and visna virus was lower than the sequence homology observed between the genomes of visna virus and progressive pneumonia virus, or between the genomes of caprine arthritis-encephalitis virus and progressive pneumonia virus. All this indicates that caprine arthritis-encephalitis virus is an additional distinct member of the Lentivirus group of the Retroviridae family.
UR - http://www.scopus.com/inward/record.url?scp=0020677809&partnerID=8YFLogxK
U2 - 10.1016/0042-6822(83)90305-7
DO - 10.1016/0042-6822(83)90305-7
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AN - SCOPUS:0020677809
SN - 0042-6822
VL - 124
SP - 192
EP - 195
JO - Virology
JF - Virology
IS - 1
ER -
