The caprine arthritis-encephalitis virus is a distinct virus within the lentivirus group

Arnona Gazit, Abraham Yaniv, Malca Dvir, Kalman Perk, Steven G. Irving, John E. Dahlberg

Research output: Contribution to journalArticlepeer-review

Abstract

The genetic relatedness among viral genomes of caprine arthritis-encephalitis virus, visna virus, and progressive pneumonia virus, was determined. Whereas the genomic RNAS of two strains of visna virus are indistinguishable as reflected both by their annealing kinetics as well as by the thermal stability of the hybrids, the caprine arthritis-encephalitis virus and visna virus have only 30% of their nucleic acid sequences in common. Furthermore, within the homologous regions of the two viral genomes, there is a significant level (∼10%) of mismatched base pairs. This limited homology that exists between caprine arthritis-encephalitis virus and visna virus was lower than the sequence homology observed between the genomes of visna virus and progressive pneumonia virus, or between the genomes of caprine arthritis-encephalitis virus and progressive pneumonia virus. All this indicates that caprine arthritis-encephalitis virus is an additional distinct member of the Lentivirus group of the Retroviridae family.

Original languageEnglish
Pages (from-to)192-195
Number of pages4
JournalVirology
Volume124
Issue number1
DOIs
StatePublished - 15 Jan 1983

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