The Cannabinoids Effect on Bone Formation and Bone Healing

Bitya Raphael-Mizrahi; Yankel Gabet

doi:10.1007/s11914-020-00607-1

The Cannabinoids Effect on Bone Formation and Bone Healing

Bitya Raphael-Mizrahi^*, Yankel Gabet

^*Corresponding author for this work

Anatomy and Anthropology

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

Purpose of Review: Here, we overview the latest findings from studies investigating the skeletal endocannabinoid (EC) system and its involvement in bone formation and resorption. Recent Findings: The endocannabinoid system consists of endogenous ligands, receptors, and enzymes. The main cannabinoids found in the cannabis plant are Δ⁹-tetrahydrocannabinol (THC) and cannabidiol (CBD). Cannabinoid receptors CB1 and CB2 are expressed in bone and regulate bone homeostasis in rodents and humans. CBD treatment was shown to enhance fracture healing in rats. Recent studies in mice indicate that strain, age, and sex differences dictate the skeletal outcome of the EC activation. Summary: CBD treatment was shown to enhance bone healing, but needs validation in clinical trials. While research shows that EC activity protects against bone loss, studies on CB1 and CB2 agonists in bone regeneration models are lacking. Whether modulating the EC system would affect bone repair remains therefore an open question worth investigating.

Original language	English
Pages (from-to)	433-438
Number of pages	6
Journal	Current Osteoporosis Reports
Volume	18
Issue number	5
DOIs	https://doi.org/10.1007/s11914-020-00607-1
State	Published - 1 Oct 2020

Keywords

Bone
CB1 receptor
CB2 receptor
CBD
Cannabinoid
Cannabis
Endocannabinoid
Fracture
Osteoporosis
Skeleton

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10.1007/s11914-020-00607-1

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title = "The Cannabinoids Effect on Bone Formation and Bone Healing",

abstract = "Purpose of Review: Here, we overview the latest findings from studies investigating the skeletal endocannabinoid (EC) system and its involvement in bone formation and resorption. Recent Findings: The endocannabinoid system consists of endogenous ligands, receptors, and enzymes. The main cannabinoids found in the cannabis plant are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Cannabinoid receptors CB1 and CB2 are expressed in bone and regulate bone homeostasis in rodents and humans. CBD treatment was shown to enhance fracture healing in rats. Recent studies in mice indicate that strain, age, and sex differences dictate the skeletal outcome of the EC activation. Summary: CBD treatment was shown to enhance bone healing, but needs validation in clinical trials. While research shows that EC activity protects against bone loss, studies on CB1 and CB2 agonists in bone regeneration models are lacking. Whether modulating the EC system would affect bone repair remains therefore an open question worth investigating.",

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AB - Purpose of Review: Here, we overview the latest findings from studies investigating the skeletal endocannabinoid (EC) system and its involvement in bone formation and resorption. Recent Findings: The endocannabinoid system consists of endogenous ligands, receptors, and enzymes. The main cannabinoids found in the cannabis plant are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Cannabinoid receptors CB1 and CB2 are expressed in bone and regulate bone homeostasis in rodents and humans. CBD treatment was shown to enhance fracture healing in rats. Recent studies in mice indicate that strain, age, and sex differences dictate the skeletal outcome of the EC activation. Summary: CBD treatment was shown to enhance bone healing, but needs validation in clinical trials. While research shows that EC activity protects against bone loss, studies on CB1 and CB2 agonists in bone regeneration models are lacking. Whether modulating the EC system would affect bone repair remains therefore an open question worth investigating.

KW - Bone

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KW - CB2 receptor

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KW - Cannabinoid

KW - Cannabis

KW - Endocannabinoid

KW - Fracture

KW - Osteoporosis

KW - Skeleton

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The Cannabinoids Effect on Bone Formation and Bone Healing

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