The Big Potential of Small Particles: Lipid-Based Nanoparticles and Exosomes in Vaccination

Marina Ben Shimon; Shiran Shapira; Jonathan Seni; Nadir Arber

doi:10.3390/vaccines10071119

The Big Potential of Small Particles: Lipid-Based Nanoparticles and Exosomes in Vaccination

Marina Ben Shimon, Shiran Shapira, Jonathan Seni, Nadir Arber^*

^*Corresponding author for this work

The Health Promotion Center and Integrated Cancer Prevention Center

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Some of the most significant medical achievements in recent history are the development of distinct and effective vaccines, and the improvement of the efficacy of previously existing ones, which have contributed to the eradication of many dangerous and life-threatening diseases. Immunization depends on the generation of a physiological memory response and protection against infection. It is therefore crucial that antigens are delivered in an efficient manner, to elicit a robust immune response. The recent approval of COVID-19 vaccines containing lipid nanoparticles encapsulating mRNA demonstrates the broad potential of lipid-based delivery systems. In light of this, the present review article summarizes currently synthesized lipid-based nanoparticles such as liposomes, lipid-nano particles, or cell-derived exosomes.

Original language	English
Article number	1119
Journal	Vaccines
Volume	10
Issue number	7
DOIs	https://doi.org/10.3390/vaccines10071119
State	Published - Jul 2022

Keywords

adjuvant
exosomes
nanotechnology
vaccines

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/vaccines10071119

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title = "The Big Potential of Small Particles: Lipid-Based Nanoparticles and Exosomes in Vaccination",

abstract = "Some of the most significant medical achievements in recent history are the development of distinct and effective vaccines, and the improvement of the efficacy of previously existing ones, which have contributed to the eradication of many dangerous and life-threatening diseases. Immunization depends on the generation of a physiological memory response and protection against infection. It is therefore crucial that antigens are delivered in an efficient manner, to elicit a robust immune response. The recent approval of COVID-19 vaccines containing lipid nanoparticles encapsulating mRNA demonstrates the broad potential of lipid-based delivery systems. In light of this, the present review article summarizes currently synthesized lipid-based nanoparticles such as liposomes, lipid-nano particles, or cell-derived exosomes.",

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The Big Potential of Small Particles: Lipid-Based Nanoparticles and Exosomes in Vaccination

Abstract

Keywords

UN SDGs

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