The bacteriology of recurrent acute exacerbations of chronic rhinosinusitis: a longitudinal analysis

Dan Yaniv, Daniel Stern, Igor Vainer, Haim Ben Zvi, Dafna Yahav, Ethan Soudry

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The purpose of this study was to describe the microbiology of recurrent acute exacerbations of chronic rhinosinusitis over time. Methods: Retrospective review of patients with recurrent acute exacerbations of chronic rhinosinusitis who underwent endoscopic-guided cultures during acute exacerbations of chronic rhinosinusitis. Results: 386 cultures were obtained from 112 patients during recurrent acute exacerbations of CRS. A change of bacterial isolates during the course of recurrent exacerbations was observed in 68% (76/112) of patients, necessitating a change of treatment in 40% (45/112). The main risk factor for the subsequent change in cultures was polymicrobial growth. Sinus surgery was not associated with subsequent change in cultured isolates. Resistant strains developed in 11.6% (13/112) of patients, of whom those with abnormal mucociliary clearance being at the highest risk. Conclusion: Repeated middle meatal cultures should be considered in patients with recurrent exacerbations of CRS, particularly in cases not responding to standard therapy.

Original languageEnglish
Pages (from-to)3051-3057
Number of pages7
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume277
Issue number11
DOIs
StatePublished - 1 Nov 2020

Keywords

  • Acute
  • Antibiotics
  • Bacteriology
  • Culture
  • Infection
  • Microbiology
  • Middle meatus
  • Recurrent
  • Rhinosinusitis
  • Sinusitis

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