The bacterial CRISPR/Cas system as analog of the mammalian adaptive immune system

Moran G. Goren, Ido Yosef, Rotem Edgar, Udi Qimron*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Bacteria, like mammals, have to constantly defend themselves from viral attack. Like mammals, they use both innate and adaptive defense mechanisms. In this point of view we highlight the commonalities between defense systems of bacteria and mammals. Our focus is on the recently discovered bacterial adaptive immune system, the clustered regularly interspaced short palindromic repeats (CRISPR) and their associated proteins (Cas). We suggest that fundamental aspects of CRISPR/Cas immunity may be viewed in light of the vast accumulated knowledge on the mammalian immune system, and propose that further insights will be revealed by thorough comparison between the systems.

Original languageEnglish
Pages (from-to)549-554
Number of pages6
JournalRNA Biology
Volume9
Issue number5
DOIs
StatePublished - May 2012

Funding

FundersFunder number
United States-Israel Binational Science FoundationPIRG-GA-2009-256340, 2009218
Israel Science Foundation611/10

    Keywords

    • Chaperones
    • Defense mechanism
    • Innate immunity

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