TY - JOUR
T1 - The ATM protein kinase
T2 - Regulating the cellular response to genotoxic stress, and more
AU - Shiloh, Yosef
AU - Ziv, Yael
N1 - Funding Information:
The authors thank Z.-Q Wang, C. Bakkenist, A. Gross, A. Barzilai, M. Lavin, S. El-Khamisy, H. Sharfi, D. Delia, A. Bensimon, R. Jachimowicz, R. Elkon and the members of The David and Inez Myers Laboratory for Cancer Genetics for very useful comments, A. Paz and G. Mass for data management and creative artwork, and F. Zetland for editing the manuscript. Work in the authors laboratory is supported by the David and Inez Myers Foundation, the Ataxia-Telangiectasia (A-T) Medical Research Foundation, the Israel Science Foundation, the A-T Ease Foundation, the Israel Cancer Research Fund, the German–Israeli Foundation for Scientific Research and Development, the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, the Israeli Centers for Research Excellence (I-CORE) Program of the Planning and Budgeting Committee and the Israel Science Foundation. Y.S. is a Research Professor of the Israel Cancer Research Fund.
PY - 2013/4
Y1 - 2013/4
N2 - The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an apical activator of the DNA damage response in the face of DNA double-strand breaks (DSBs). Following induction of DSBs, ATM mobilizes one of the most extensive signalling networks that responds to specific stimuli and modifies directly or indirectly a broad range of targets. Although most ATM research has focused on this function, evidence suggests that ATM-mediated phosphorylation has a role in the response to other types of genotoxic stress. Moreover, it has become apparent that ATM is active in other cell signalling pathways involved in maintaining cellular homeostasis.
AB - The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an apical activator of the DNA damage response in the face of DNA double-strand breaks (DSBs). Following induction of DSBs, ATM mobilizes one of the most extensive signalling networks that responds to specific stimuli and modifies directly or indirectly a broad range of targets. Although most ATM research has focused on this function, evidence suggests that ATM-mediated phosphorylation has a role in the response to other types of genotoxic stress. Moreover, it has become apparent that ATM is active in other cell signalling pathways involved in maintaining cellular homeostasis.
UR - http://www.scopus.com/inward/record.url?scp=84875423827&partnerID=8YFLogxK
U2 - 10.1038/nrm3546
DO - 10.1038/nrm3546
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AN - SCOPUS:84875423827
SN - 1471-0072
VL - 14
SP - 197
EP - 210
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 4
ER -