TY - JOUR
T1 - The association of crown-rump length discrepancy with birthweight discordance in spontaneous versus IVF monochorionic twins
T2 - A multicenter study
AU - Ben-Ami, Ido
AU - Daniel-Spiegel, Etty
AU - Battino, Shlomo
AU - Melcer, Yaakov
AU - Floeck, Anne
AU - Geipel, Annegret
AU - Miron, Pierre
AU - Maymon, Ron
N1 - Publisher Copyright:
© 2015 John Wiley & Sons, Ltd.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Objective: The objective of this study was to compare the associations of crown-rump length (CRL) discrepancy with birthweight discordance in spontaneous versus in vitro fertilization (IVF) monochorionic (MC) twin pregnancies. Method: This is a multicenter retrospective study on women with twin pregnancies assessed for nuchal translucency between January 1997 and July 2013. The study group was subdivided into MC twins conceived spontaneously and after IVF. Pregnancies with later fetal death or twin transfusion syndrome were excluded. A large-weight discordance was defined as a difference of birthweights of >15%. Results: The study group included 171 pregnancies; of them, 142 (83%) were spontaneous and 29 (17%) were IVF conceived. In the entire cohort, we found a significant correlation between birthweight discordance and CRL discrepancy (r=0.173, P<0.05). While a significant correlation was found between CRL discrepancy and birthweight discordance in spontaneous-conceived pregnancies (n=142, r=0.24, P=0.005), such correlation was not present in IVF pregnancies (n=29, r=-0.7, P=0.724). A logistic regression analysis found significant odds of larger-weight discordance for each increase of 1% in CRL discrepancy among spontaneously conceived pregnancies (odds ratio=1.1, confidence interval=1.03-1.2, P=0.005). A receiver operating characteristic (ROC) for large-weight discordance in the spontaneously conceived pregnancies demonstrated an area under the ROC curve of 0.613 (P=0.039). Conclusion: The significant correlation between CRL discrepancy and birthweight discordance in spontaneous versus IVF MC twin pregnancies might suggest differential monozygotic twinning process.
AB - Objective: The objective of this study was to compare the associations of crown-rump length (CRL) discrepancy with birthweight discordance in spontaneous versus in vitro fertilization (IVF) monochorionic (MC) twin pregnancies. Method: This is a multicenter retrospective study on women with twin pregnancies assessed for nuchal translucency between January 1997 and July 2013. The study group was subdivided into MC twins conceived spontaneously and after IVF. Pregnancies with later fetal death or twin transfusion syndrome were excluded. A large-weight discordance was defined as a difference of birthweights of >15%. Results: The study group included 171 pregnancies; of them, 142 (83%) were spontaneous and 29 (17%) were IVF conceived. In the entire cohort, we found a significant correlation between birthweight discordance and CRL discrepancy (r=0.173, P<0.05). While a significant correlation was found between CRL discrepancy and birthweight discordance in spontaneous-conceived pregnancies (n=142, r=0.24, P=0.005), such correlation was not present in IVF pregnancies (n=29, r=-0.7, P=0.724). A logistic regression analysis found significant odds of larger-weight discordance for each increase of 1% in CRL discrepancy among spontaneously conceived pregnancies (odds ratio=1.1, confidence interval=1.03-1.2, P=0.005). A receiver operating characteristic (ROC) for large-weight discordance in the spontaneously conceived pregnancies demonstrated an area under the ROC curve of 0.613 (P=0.039). Conclusion: The significant correlation between CRL discrepancy and birthweight discordance in spontaneous versus IVF MC twin pregnancies might suggest differential monozygotic twinning process.
UR - http://www.scopus.com/inward/record.url?scp=84940789341&partnerID=8YFLogxK
U2 - 10.1002/pd.4623
DO - 10.1002/pd.4623
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C2 - 25989950
AN - SCOPUS:84940789341
SN - 0197-3851
VL - 35
SP - 864
EP - 869
JO - Prenatal Diagnosis
JF - Prenatal Diagnosis
IS - 9
ER -