TY - JOUR
T1 - The Association between Sex and Long-Term Pediatric Cardiovascular Morbidity
AU - Sheiner, Eyal
AU - Wainstock, Tamar
AU - Landau, Daniella
AU - Walfisch, Asnat
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Objective To evaluate the association between sex and long-term pediatric cardiovascular morbidity. Study design A population-based cohort study was performed that compared the risk of long-term cardiovascular morbidity (up to the age of 18 years) of children according to sex. Deliveries occurred between the years 1991 and 2013 in a tertiary medical center. Multiple pregnancies and fetal congenital malformations were excluded. Kaplan-Meier survival curves were constructed to compare cumulative cardiovascular morbidity incidence. A Cox proportional hazards model was used to control for confounders, including gestational age at birth, birth weight, and maternal factors. Results During the study period, 240 953 newborns met the inclusion criteria and were included in the long-term analysis. Of them, 51.0% (n = 122 840) were male and 49.0% (n = 118 113) female. Cardiovascular morbidity up to the age of 18 years was significantly more common in male as compared with female newborns (0.3% vs 0.2%, OR 1.33, 95% CI 1.12-1.57, P = .001). In the Cox regression model, male sex exhibited an independent association with long-term cardiovascular morbidity with an adjusted hazard ratio of 1.37 (95% CI 1.16-1.63, P < .001). Conclusion Male newborns are at an increased risk for pediatric cardiovascular morbidity independent of gestational age at birth and birth weight.
AB - Objective To evaluate the association between sex and long-term pediatric cardiovascular morbidity. Study design A population-based cohort study was performed that compared the risk of long-term cardiovascular morbidity (up to the age of 18 years) of children according to sex. Deliveries occurred between the years 1991 and 2013 in a tertiary medical center. Multiple pregnancies and fetal congenital malformations were excluded. Kaplan-Meier survival curves were constructed to compare cumulative cardiovascular morbidity incidence. A Cox proportional hazards model was used to control for confounders, including gestational age at birth, birth weight, and maternal factors. Results During the study period, 240 953 newborns met the inclusion criteria and were included in the long-term analysis. Of them, 51.0% (n = 122 840) were male and 49.0% (n = 118 113) female. Cardiovascular morbidity up to the age of 18 years was significantly more common in male as compared with female newborns (0.3% vs 0.2%, OR 1.33, 95% CI 1.12-1.57, P = .001). In the Cox regression model, male sex exhibited an independent association with long-term cardiovascular morbidity with an adjusted hazard ratio of 1.37 (95% CI 1.16-1.63, P < .001). Conclusion Male newborns are at an increased risk for pediatric cardiovascular morbidity independent of gestational age at birth and birth weight.
KW - Arrhythmia
KW - Boys
KW - Epidemiology
KW - Heart disease
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=85006741788&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2016.09.014
DO - 10.1016/j.jpeds.2016.09.014
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C2 - 27745861
AN - SCOPUS:85006741788
SN - 0022-3476
VL - 180
SP - 68-73.e1
JO - Journal of Pediatrics
JF - Journal of Pediatrics
ER -