The association between severe fetal congenital heart defects and placental vascular malperfusion lesions

Hadas Miremberg*, Liat Gindes, Letizia Schreiber, Alona Raucher Sternfeld, Jacob Bar, Michal Kovo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Objective: Studies have shown an association between infant with congenital heart defects (CHD) and the risk of preeclampsia. We aimed to characterize placental histopathology from pregnancies who underwent termination of pregnancy (TOP) because of severe CHD. Methods: This was a case control study. The medical files of all TOPs due to fetal congenital malformations were reviewed. Cases with CHD included hypoplastic left heart, transposition of great arteries, AV canal, tetralogy of Fallot, double outlet RV, and coractation of aorta. The controls included TOPs due to congenital central nervous system defects (CNS group) that were matched in a 1:1 ratio, by gestational age and maternal age. Placental lesions were classified to maternal and fetal vascular malperfusion (MVM and FVM) and inflammatory lesions. Results: Higher rates of any MVM or FVM lesion were observed in placentas from the CHD group (n = 32) as compared with the CNS group (n = 32), 40.6% versus 12.5% respectively, p =.02. As compared with the CNS group, the CHD group had more abnormal coiling of umbilical cord (p =.01). Conclusion: Placental vascular malperfusion lesions are more common in pregnancies complicated with CHD as compared with CNS malformations. These findings support the hypothesis of similar etiopathogenetic factors, contributing to the development of preeclampsia and CHD.

Original languageEnglish
Pages (from-to)962-967
Number of pages6
JournalPrenatal Diagnosis
Issue number11
StatePublished - 1 Oct 2019
Externally publishedYes


Dive into the research topics of 'The association between severe fetal congenital heart defects and placental vascular malperfusion lesions'. Together they form a unique fingerprint.

Cite this