The association between serum creatine kinase, mood and psychosis in inpatients with schizophrenia, bipolar and schizoaffective disorders

Sarah Hollander, Eldar Hochman, Gal Shoval, Michal Taler, Sharon Trommer, Haggai Hermesh, Abraham Weizman, Amir Krivoy

Research output: Contribution to journalArticlepeer-review

Abstract

Previous studies demonstrated levels of serum CK (sCK) in the majority of patients undergoing acute psychosis. Records of 1054 patients hospitalized in Geha Mental Health Center during the study period were analyzed. Of them, 743 have been diagnosed with schizophrenia (Sz), 170 with schizoaffective disorder (SzA), and 158 with bipolar disorder (BP-I). Baseline sCK and PANSS values were obtained from each patient upon admission. Our results show that LnsCK is higher in patients with BP-I in comparison with patients with SZ, but not significantly different compared to patients with SzA. A multivariate analysis using linear regression model in which LnsCK was predicted by factors such as PANSS-total and sub-scores, IM injection, BMI, gender, and age among patients at each admission, revealed that PANSS-depression was inversely associated with LnsCK level in SzA and BP-I and not in SZ. A positive association was found between PANSS-total and sCK in SzA and BP-I; however, PANSS-positive scores correlated with sCK only in SzA. After controlling for confounders, it seems that sCK level is associated with the both affective and psychotic components. Serum CK may serve as a biomarker for affective exacerbation rather than psychosis.

Original languageEnglish
Pages (from-to)333-337
Number of pages5
JournalPsychiatry Research
Volume238
DOIs
StatePublished - 30 Apr 2016

Keywords

  • Affect
  • Bipolar disorder
  • Creatine kinase
  • Depression
  • Mood disorders
  • Psychopathology
  • Psychotic disorders

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