TY - JOUR
T1 - The Association Between Hypothyroidism Treatment and Mortality in Patients Hospitalized in Surgical Wards
AU - Masri-Iraqi, Hiba
AU - Rudman, Yaron
AU - Friedrich Dubinchik, Carmel
AU - Dotan, Idit
AU - Diker-Cohen, Talia
AU - Sasson, Liat
AU - Shochat, Tzipora
AU - Shimon, Ilan
AU - Robenshtok, Eyal
AU - Akirov, Amit
N1 - Publisher Copyright:
© 2023 Taylor & Francis Group, LLC.
PY - 2023
Y1 - 2023
N2 - Limited data are available regarding the association between pre-admission thyroid-stimulating hormone (TSH) levels and prognosis in hospitalized surgical patients treated for hypothyroidism. We retrospectively evaluated a cohort of 1,451 levothyroxine-treated patients, hospitalized to general surgery wards. The 30-day mortality risk was 2-fold higher for patients with TSH of 5.0–10.0 mIU/L (adjusted OR, 2.3; 95% CI 1.1–5.1), and 3-fold higher for those with TSH > 10.0 mIU/L (3.4; 95% CI 1.3–8.7). Long-term mortality risk was higher in patients with TSH of 5.0–10.0 and above 10.0 mIU/L (adjusted HR, 1.2; 95% CI, 1.0–1.6, and 1.7; 95% CI 1.2–2.4, respectively). We found that in levothyroxine-treated adults hospitalized to surgical wards, increased pre-admission TSH levels are associated with increased short- and long-term mortality.
AB - Limited data are available regarding the association between pre-admission thyroid-stimulating hormone (TSH) levels and prognosis in hospitalized surgical patients treated for hypothyroidism. We retrospectively evaluated a cohort of 1,451 levothyroxine-treated patients, hospitalized to general surgery wards. The 30-day mortality risk was 2-fold higher for patients with TSH of 5.0–10.0 mIU/L (adjusted OR, 2.3; 95% CI 1.1–5.1), and 3-fold higher for those with TSH > 10.0 mIU/L (3.4; 95% CI 1.3–8.7). Long-term mortality risk was higher in patients with TSH of 5.0–10.0 and above 10.0 mIU/L (adjusted HR, 1.2; 95% CI, 1.0–1.6, and 1.7; 95% CI 1.2–2.4, respectively). We found that in levothyroxine-treated adults hospitalized to surgical wards, increased pre-admission TSH levels are associated with increased short- and long-term mortality.
KW - Hypothyroidism
KW - mortality
KW - surgery
KW - thyroid replacement therapy
UR - http://www.scopus.com/inward/record.url?scp=85161414116&partnerID=8YFLogxK
U2 - 10.1080/07435800.2023.2220022
DO - 10.1080/07435800.2023.2220022
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C2 - 37259228
AN - SCOPUS:85161414116
SN - 0743-5800
VL - 48
SP - 68
EP - 76
JO - Endocrine Research
JF - Endocrine Research
IS - 2-3
ER -