TY - JOUR
T1 - The association between giant cell arteritis and ischemic heart disease
T2 - A population-based cross-sectional study
AU - Dagan, Amir
AU - Mahroum, Naim
AU - Segal, Gad
AU - Tiosano, Shmuel
AU - Watad, Abdulla
AU - Comaneshter, Doron
AU - Cohen, Arnon D.
AU - Amital, Howard
N1 - Publisher Copyright:
© 2017, Israel Medical Association. All right reserved.
PY - 2017/8/2
Y1 - 2017/8/2
N2 - Background: Patients with giant cell arteritis (GCA) suffer from inflammatory diseases often treated by large amounts of corticosteroids. Whether this inflammatory burden also carries an increased risk for cardiovascular morbidity, and especially ischemic heart disease, is not clearly established. Objectives: To clarify the linkage between GCA and ischemic heart disease. Methods: In a cross-sectional study, we assessed the association between GCA and ischemic heart disease, adjusting for cardiovascular risk factors, among GCA patients and matched controls using the database of the largest healthcare provider in Israel. Results: The study group was comprised of 5659 GCA patients and 28,261 age and gender matched controls. The proportion of ischemic heart disease was higher in the GCA group (27.5% vs. 12.5% among controls, odds ratio 2.65). Diabetes mellitus, hypertension, hyperlipidemia and smoking were also found to have higher concurrency in GCA. After stratifying for those cardiovascular co-morbidities using logistic regression, GCA remained independently associated with ischemic heart disease with an odds ratio of 1.247 (1.146-1.357 P < 0.001). Conclusions: GCA is associated with both cardiovascular risk factors and ischemic heart disease. Healthcare professionals should not overlook this aspect of the disease when managing GCA patients.
AB - Background: Patients with giant cell arteritis (GCA) suffer from inflammatory diseases often treated by large amounts of corticosteroids. Whether this inflammatory burden also carries an increased risk for cardiovascular morbidity, and especially ischemic heart disease, is not clearly established. Objectives: To clarify the linkage between GCA and ischemic heart disease. Methods: In a cross-sectional study, we assessed the association between GCA and ischemic heart disease, adjusting for cardiovascular risk factors, among GCA patients and matched controls using the database of the largest healthcare provider in Israel. Results: The study group was comprised of 5659 GCA patients and 28,261 age and gender matched controls. The proportion of ischemic heart disease was higher in the GCA group (27.5% vs. 12.5% among controls, odds ratio 2.65). Diabetes mellitus, hypertension, hyperlipidemia and smoking were also found to have higher concurrency in GCA. After stratifying for those cardiovascular co-morbidities using logistic regression, GCA remained independently associated with ischemic heart disease with an odds ratio of 1.247 (1.146-1.357 P < 0.001). Conclusions: GCA is associated with both cardiovascular risk factors and ischemic heart disease. Healthcare professionals should not overlook this aspect of the disease when managing GCA patients.
KW - Autoimmunity
KW - Cardiovascular disease
KW - Giant cell arteritis
KW - Inflammation
KW - Ischemic heart disease
UR - http://www.scopus.com/inward/record.url?scp=85026821960&partnerID=8YFLogxK
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 28786254
AN - SCOPUS:85026821960
SN - 1565-1088
VL - 19
SP - 411
EP - 414
JO - Israel Medical Association Journal
JF - Israel Medical Association Journal
IS - 7
ER -