TY - JOUR
T1 - The association between burnout, depression, anxiety, and inflammation biomarkers
T2 - C-reactive protein and fibrinogen in men and women
AU - Toker, Sharon
AU - Shirom, Arie
AU - Shapira, Itzhak
AU - Berliner, Shlomo
AU - Melamed, Samuel
PY - 2005/10
Y1 - 2005/10
N2 - Following the demonstrated association of employee burnout or vital exhaustion with several risk factors for cardiovascular disease (CVD) and CVD risk, the authors investigated the possibility that one of the mechanisms linking burnout with CVD morbidity is microinflammation, gauged in this study by high-sensitivity C-reactive protein (hs-CRP) and fibrinogen concentrations. Their sample included 630 women and 933 men, all apparently healthy, who underwent periodic health examinations. The authors controlled for possible confounders including 2 other negative affective states: depression and anxiety. In women, burnout was positively associated with hs-CRP and fibrinogen concentrations, and anxiety was negatively associated with them. In men, depression was positively associated with hs-CRP and fibrinogen concentrations, but not with burnout or anxiety. Thus, burnout, depression, and anxiety are differentially associated with microinflammation biomarkers, dependent on gender.
AB - Following the demonstrated association of employee burnout or vital exhaustion with several risk factors for cardiovascular disease (CVD) and CVD risk, the authors investigated the possibility that one of the mechanisms linking burnout with CVD morbidity is microinflammation, gauged in this study by high-sensitivity C-reactive protein (hs-CRP) and fibrinogen concentrations. Their sample included 630 women and 933 men, all apparently healthy, who underwent periodic health examinations. The authors controlled for possible confounders including 2 other negative affective states: depression and anxiety. In women, burnout was positively associated with hs-CRP and fibrinogen concentrations, and anxiety was negatively associated with them. In men, depression was positively associated with hs-CRP and fibrinogen concentrations, but not with burnout or anxiety. Thus, burnout, depression, and anxiety are differentially associated with microinflammation biomarkers, dependent on gender.
UR - http://www.scopus.com/inward/record.url?scp=27744563032&partnerID=8YFLogxK
U2 - 10.1037/1076-8998.10.4.344
DO - 10.1037/1076-8998.10.4.344
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C2 - 16248685
AN - SCOPUS:27744563032
SN - 1076-8998
VL - 10
SP - 344
EP - 362
JO - Journal of Occupational Health Psychology
JF - Journal of Occupational Health Psychology
IS - 4
ER -