The association between burnout, depression, anxiety, and inflammation biomarkers: C-reactive protein and fibrinogen in men and women

Sharon Toker*, Arie Shirom, Itzhak Shapira, Shlomo Berliner, Samuel Melamed

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

251 Scopus citations

Abstract

Following the demonstrated association of employee burnout or vital exhaustion with several risk factors for cardiovascular disease (CVD) and CVD risk, the authors investigated the possibility that one of the mechanisms linking burnout with CVD morbidity is microinflammation, gauged in this study by high-sensitivity C-reactive protein (hs-CRP) and fibrinogen concentrations. Their sample included 630 women and 933 men, all apparently healthy, who underwent periodic health examinations. The authors controlled for possible confounders including 2 other negative affective states: depression and anxiety. In women, burnout was positively associated with hs-CRP and fibrinogen concentrations, and anxiety was negatively associated with them. In men, depression was positively associated with hs-CRP and fibrinogen concentrations, but not with burnout or anxiety. Thus, burnout, depression, and anxiety are differentially associated with microinflammation biomarkers, dependent on gender.

Original languageEnglish
Pages (from-to)344-362
Number of pages19
JournalJournal of Occupational Health Psychology
Volume10
Issue number4
DOIs
StatePublished - Oct 2005

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