The Association between Advanced Maternal Age and the Manifestations of Preeclampsia with Severe Features

Itamar Gilboa, Michael Kupferminc, Anat Schwartz, Yisca Landsberg Ashereh, Yariv Yogev, Avital Rappaport Skornik, Chagit Klieger, Liran Hiersch, Eli Rimon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

This retrospective cohort study aimed to explore the association between advanced maternal age and the clinical manifestations as well as laboratory parameters of preeclampsia with severe features. This study included 452 patients who were diagnosed with preeclampsia with severe features. The clinical and laboratorial characteristics of patients with preeclampsia with severe features aged ≥40 years old (study group) were compared to those of patients aged <40 years old (control group). Multivariant analysis was applied to assess the association between advanced maternal age and the manifestations of preeclampsia with severe features, adjusting for the variables that exhibited significant differences between the study and control groups. The multivariate analysis revealed that a maternal age of ≥40 years old was an independent risk factor for acute kidney injury (OR = 2.5, CI = 1.2–4.9, p = 0.011) and for new-onset postpartum preeclampsia (OR = 2.4, CI = 1.0–5.6, p = 0.046). Conversely, a maternal age ≥ 40 years old was associated with a reduced risk of HELLP syndrome (OR = 0.4, CI = 0.2–0.9, p = 0.018) and thrombocytopenia (OR = 0.5, CI = 0.3–0.9, p = 0.016) compared to that of the patients < 40 years of age. In conclusion, this study demonstrates that maternal age is significantly associated with the clinical manifestations and laboratory parameters of preeclampsia with severe features, highlighting the importance of age-specific management.

Original languageEnglish
Article number6545
JournalJournal of Clinical Medicine
Volume12
Issue number20
DOIs
StatePublished - Oct 2023
Externally publishedYes

Keywords

  • HELLP syndrome
  • advanced maternal age
  • preeclampsia with severe features

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