The association between adipocytokines and glycemic control in women with gestational diabetes mellitus

Amir Aviram*, Biana Shtaif, Galia Gat-Yablonski, Yariv Yogev

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate the relationship between adipocytokines and glycemic control. Study design: Prospective observational trial of gestations with gestational diabetes mellitus (GDM). Fasting glucose (FG), insulin, adiponectin, leptin, chemerin, retinol-binding protein 4 (RBP-4), osteocalcin, and resistin were measured. HomeOstasis model assessment of insulin resistance (HOMA-IR) and QUantitative insulin sensitivity ChecK Index (QUICKI) were calculated. Women who required medications for glycemic control were compared to women using nutritional therapy only. Results: Overall, 75 women were included −26 (34.7%) required medications to achieve good glycemic control. Factors associated with poor control are as follows: low resistin (aOR 0.84), HOMA-IR (aOR 1.96), QUICKI (aOR 0.62), first trimester FG (aOR 1.43), and maternal age (aOR 1.26). HOMA-IR and QUICKI performed highest for prediction. Resistin, first trimester FG, maternal age, and QUICKI had an AUC of 0.878, sensitivity and specificity of 87.5% for the prediction of the need for medications. Conclusions: Low resistin is associated with poor control. A model utilizing maternal age, first trimester fasting glucose, and first visit QUICKI yields good predictability.

Original languageEnglish
Pages (from-to)177-183
Number of pages7
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume33
Issue number2
DOIs
StatePublished - 17 Jan 2020

Funding

FundersFunder number
Petah Tikva, Israel

    Keywords

    • Adipocytokines
    • gestational diabetes mellitus
    • glycemic control
    • therapy intervention

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