The association between ABO blood group and obstetric hemorrhage

Lior Drukker, Naama Srebnik*, Deborah Elstein, Lorinne Levitt, Arnon Samueloff, Rivka Farkash, Sorina Grisaru-Granovsky, Hen Y. Sela

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Whether intra- and early post-partum hemorrhage is influenced by ABO blood groups remains unknown. Therefore, we compared women with O to non-O blood groups with regard to maternal post-partum hemorrhage and transfusion need. This retrospective study was conducted in a single tertiary center between 2005 and 2014. For the purpose of the study, parturients were categorized as O and non-O blood groups. Data included all deliveries but excluded patients with missing blood grouping or hemoglobin values, and/or stillbirth. Drop in hemoglobin was defined as hemoglobin concentration at admission for delivery minus lowest hemoglobin concentration post-delivery. Study outcomes were postpartum hemorrhage, hemoglobin drop >2–7 g/dL inclusive, and packed red blood cells transfusion. Statistics: descriptive, χ2 (p < 0.05 significant) and multivariable regression models [odds ratio (OR), 95 % confidence interval (CI), p value]. 125,768 deliveries were included. After multivariable analysis, women with O blood type relative to women with non-O blood type had significantly higher odds of postpartum hemorrhage (OR 1.14; 95 % CI 1.05–1.23, p < 0.001), higher odds of statistically significant hemoglobin decreases of >2, 3, or 4 g/dL (OR 1.07; 95 % CI 1.04–1.11, p < 0.001, OR 1.08; 95 % CI 1.03–1.14, p = 0.002, OR 1.14; 95 % CI 1.05–1.23, p = 0.001; respectively), and higher odds, albeit not statistically significant of 5, 6, or 7 g/dL decreases in hemoglobin (OR 1.13; 95 % CI 1.00–1.29, p = 0.055, OR 1.05; 95 % CI 0.84–1.32, p = 0.66, OR 1.15; 95 % CI 0.79–1.68, p = 0.46; respectively), but no difference in blood products transfusion (OR 1.03; 95 % CI 0.92–1.16, p = 0.58). In conclusion, women with blood type O may be at greater risk of obstetrical hemorrhage.

Original languageEnglish
Pages (from-to)340-345
Number of pages6
JournalJournal of Thrombosis and Thrombolysis
Volume42
Issue number3
DOIs
StatePublished - 1 Oct 2016
Externally publishedYes

Keywords

  • Anemia
  • Blood group
  • Blood transfusion
  • Delivery
  • Maternal outcome
  • Postpartum hemorrhage

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