@article{f1fb9ce5ab0e4e6a873dcbd2f6ddeb7e,
title = "The Aspergillus nidulans pkcA gene is involved in polarized growth, morphogenesis and maintenance of cell wall integrity",
abstract = "The protein kinase C (PKC) family participates in maintaining integrity and growth of fungal cell walls. However, the precise molecular role of these proteins in the filamentous fungi remains unknown. In this work, pkcA, the gene encoding the PKC homolog in the filamentous fungus Aspergillus nidulans, was cloned and its function analyzed using a conditional alcA-PKC mutant strain. Repression of pkcA expression resulted in increased conidial swelling, decreased rates of hyphal growth, changes in the ultrastructure of the cell wall and increased sensitivity to antifungal agents. These results suggest that the protein encoded by pkcA is involved in key aspects of cell morphogenesis and cell wall integrity.",
keywords = "Aspergillus nidulans, Fungal cell wall, pkcA",
author = "Revital Ronen and Haim Sharon and Emma Levdansky and Jacob Romano and Yona Shadkchan and Nir Osherov",
note = "Funding Information: Acknowledgments This work was funded by the Stoltz Foundation and the Israel Academy of Sciences, grant 741/01 to NO.",
year = "2007",
month = may,
doi = "10.1007/s00294-007-0129-y",
language = "אנגלית",
volume = "51",
pages = "321--329",
journal = "Current Genetics",
issn = "0172-8083",
publisher = "Springer Science and Business Media Deutschland GmbH",
number = "5",
}