The area of the pressure - Flow loop for assessment of arterial stenosis: A new index

Zehava Ovadia-Blechmana, Shmuel Einav, Uri Zaretsky, David Castel, Eran Toledo, Michael Eldar

Research output: Contribution to journalArticlepeer-review


This study describes a novel method for assessing stenotic severity, based on simultaneous pressure and flow wave measurements. Pressure and flow measurements were performed in latex and rubber tubes, and in a clinically-used vascular graft. Pressure waves were recorded at several degrees of stenosis and at different distances proximal to the stenosis. Pressure wave versus flow wave was plotted. Internal pressure-flow loop area (PFLA), loop slope and pressure-axis intercept were calculated. Values of these three indices significantly increased with increasing degrees of stenosis (P < 0.001). Similar phenomenon was observed during in-vivo experiments. Polynomial functions were fitted, resulting in an excellent PFLA variable/ percent stenosis correlation, independent of distance between sensor and stenosis (|R| > 0.96). In addition, tube compliance was measured and found to correlate with the polynomial coefficients (|R| > 0.9). This innovative approach could significantly contribute to detecting and evaluating arterial stenoses, and to characterize the elasticity of the artery.

Original languageEnglish
Pages (from-to)39-56
Number of pages18
JournalTechnology and Health Care
Issue number1
StatePublished - 2002


  • Arterial stenosis
  • Blood flow
  • Blood pressure
  • Elasticity
  • Hemodynamics


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