The Anticancer Activity of Organotelluranes: Potential Role in Integrin Inactivation

Alon Silberman, Yona Kalechman, Shira Hirsch, Ziv Erlich, Benjamin Sredni*, Amnon Albeck

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Organic TeIV compounds (organotelluranes) differing in their labile ligands exhibited anti-integrin activities in vitro and anti-metastatic properties in vivo. They underwent ligand substitution with l-cysteine, as a thiol model compound. Unlike inorganic TeIV compounds, the organotelluranes did not form a stable complex with cysteine, but rather immediately oxidized it. The organotelluranes inhibited integrin functions, such as adhesion, migration, and metalloproteinase secretion mediation in B16F10 murine melanoma cells. In comparison, a reduced derivative with no labile ligand inhibited adhesion of B16F10 cells to a significantly lower extent, thus pointing to the importance of the labile ligands of the TeIV atom. One of the organotelluranes inhibited circulating cancer cells in vivo, possibly by integrin inhibition. Our results extend the current knowledge on the reactivity and mechanism of organotelluranes with different labile ligands and highlight their clinical potential.

Original languageEnglish
Pages (from-to)918-927
Number of pages10
Issue number10
StatePublished - 17 May 2016
Externally publishedYes


  • VLA-4
  • cancer
  • inhibitors
  • integrins
  • labile ligands
  • organotelluranes


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