The angiogenic factors CXCL8 and VEGF in breast cancer: Regulation by an array of pro-malignancy factors

Elina Azenshtein, Tsipi Meshel, Sima Shina, Nely Barak, Iafa Keydar, Adit Ben-Baruch

Research output: Contribution to journalArticlepeer-review

Abstract

The regulation of secretion of the angiogenic factors CXCL8 and Vascular Endothelial Growth Factors (VEGF) was determined in breast tumor cells and in monocytic cells (as host cells that contribute to breast cancer). CXCL8 secretion, and partly the secretion of VEGF, were up-regulated in monocytic cells, but not in breast tumor cells, by the CC chemokines CCL5 and CCL2. EGF potently up-regulated CXCL8 secretion by breast tumor cells, and its effect was promoted by a consecutive treatment of the cells by estrogen and progesterone. These findings provide evidence for a complex set of pro-malignancy factors that may control the expression of angiogenic mediators at breast tumor sites.

Original languageEnglish
Pages (from-to)73-86
Number of pages14
JournalCancer Letters
Volume217
Issue number1
DOIs
StatePublished - 10 Jan 2005

Funding

FundersFunder number
Ela Kodesz Institute for Research on Cancer Development and Prevention
Tel-Aviv
Israel Cancer Association
Ministry of Health, State of Israel

    Keywords

    • Breast cancer
    • CCL2
    • CCL5
    • CXCL8
    • EGF
    • Hormones
    • VEGF

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