@article{129483ccf5dd4d609d59e52f597838e0,
title = "The adjuvant activity of BAT antibody enables DNA vaccination to inhibit the progression of established autochthonous Her-2/neu carcinomas in BALB/c mice",
abstract = "Over the course of 33 weeks from birth, the mammary glands of virgin female BALB/c mice transgenic for the transforming rat Her-2/neu oncogene progress from atypical hyperplasia to invasive carcinoma. By week 12, all their mammary glands display many foci of in situ carcinoma. DNA vaccination at weeks 12 and 14 through in vivo electroporation of a plasmid encoding for the extracellular and transmembrane domain of the protein product of rat Her-2/neu oncogene kept 33% of mice tumor-free until week 35, when the experiment ended. To improve its efficacy the vaccine was combined with a T cell stimulatory monoclonal antibody (BAT). When each plasmid electroporation was followed by intravenous administration of 10 μg of BAT monoclonal antibody at weeks 13 and 15, 55% of mice remained tumor free (p < 0.0001) and stronger T cell and antibody-mediated immune responses were elicited. These data suggest that costimulation by BAT monoclonal antibody enables DNA vaccination to establish an effective protection against incipient carcinomas.",
keywords = "BAT mAb, HER-2/neu, Immunotherapy",
author = "Elena Quaglino and Cristina Mastini and Manuela Iezzi and Guido Forni and Piero Musiani and Klapper, {Leah N.} and Britta Hardy and Federica Cavallo",
note = "Funding Information: This work was funded by grants from the Italian Association for Cancer Research, the Italian Ministries for the University and Health, the University of Turin, Compagnia di San Paolo, Turin, and the Center of Excellence on Aging, University of Chieti, Italy. ",
year = "2005",
month = may,
day = "9",
doi = "10.1016/j.vaccine.2005.01.086",
language = "אנגלית",
volume = "23",
pages = "3280--3287",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier Ltd.",
number = "25",
}
