The adenosine-induced mechanism for the acquisition of ischemic tolerance in primary rat neuronal cultures

Ayelet Reshef, Oded Sperling*, Esther Zoref-Shani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Neurons can be preconditioned by various procedures to resist ischemic insult. The preconditioning mechanism induced by adenosine ('the adenosine mechanism') was characterized in primary rat neuronal cultures, employing a model of chemical ischemia. The protective mechanism, initiated by activation of adenosine receptors, consists of a signal transduction pathway, involving activation of protein kinase C (PKC) and opening of ATP-sensitive potassium (K(ATP)) channels. Direct activation (and inhibition) of PKC, as well as opening of K(ATP) channels, also confers protection. The opening of the K(ATP) channels mediates the signal activated by the adenosine receptors, and probably also that activated by PKC. The acquired ischemic resistance lasts up to 5 days, depending on the activating substance. The adenosine-activated cascade of events leading to ischemic tolerance in neurons is similar to that operating in cardiomyocytes. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)151-159
Number of pages9
JournalPharmacology and Therapeutics
Volume87
Issue number2-3
DOIs
StatePublished - Aug 2000

Funding

FundersFunder number
Tel Aviv University

    Keywords

    • 1,2-dioctanoyl-rac- glycerol (DOG)
    • ATP-sensitive potassium (K(ATP)) channels
    • Adenosine
    • Glibenclamide
    • N-(R)-phenylisopropyladenosine (R-PIA)
    • Protein kinase C (PKC)

    Fingerprint

    Dive into the research topics of 'The adenosine-induced mechanism for the acquisition of ischemic tolerance in primary rat neuronal cultures'. Together they form a unique fingerprint.

    Cite this