The addition of lithium salts of 0-alkyloximes to aldehydes: Synthesis of ß-keto ö-alkyloximes

Shimon Shatzmiller, Eliezer Bahar, Sorin Bercovici, Alexander Cohen, Gerhard Verdoorn

Research output: Contribution to journalArticlepeer-review

Abstract

Addition of lithium salts of oxime O-ethers to aldehydes affords the thermodynamically unfavored ^-hydroxy (Z)-O-alkyloximes. Oxidation of the hydroxy function with chromium trioxide/pyridine complex gives the ß-keto O-alkyloximes. Facile alkylation of the 1,3-dicarbonyl analogs is possible via their sodium or lithium salts.

Original languageEnglish
Pages (from-to)502-504
Number of pages3
JournalSynthesis
Volume1990
Issue number6
DOIs
StatePublished - 1990

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