TY - JOUR
T1 - The activating receptor NKG2D is an anti-fungal pattern recognition receptor
AU - Charpak-Amikam, Yoav
AU - Kournos, Mark
AU - Kotzur, Rebecca
AU - Isaacson, Batya
AU - Bagad Brenner, Tal
AU - Gomez-Cesar, Elidet
AU - Abou-Kandil, Ammar
AU - Ben-Ami, Ronen
AU - Korem, Maya
AU - Guerra, Nadia
AU - Osherov, Nir
AU - Mandelboim, Ofer
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - NKG2D is a central activating receptor involved in target recognition and killing by Natural Killer and CD8+ T cells. The known role of NKG2D is to recognize a family of self-induced stress ligands that are upregulated on stressed cells such as cancerous or virally infected cells. Fungal pathogens are a major threat to human health, infecting more than a billion patients yearly and becoming more common and drug resistant. Here we show that NKG2D plays a critical role in the immune response against fungal infections. NKG2D can recognize fungal pathogens from most major families including Candida, Cryptococcus and Aspergillus species, and mice lacking NKG2D are extremely sensitive to fungal infections in models of both invasive and mucosal infections, making NKG2D an anti-fungal pattern recognition receptor.
AB - NKG2D is a central activating receptor involved in target recognition and killing by Natural Killer and CD8+ T cells. The known role of NKG2D is to recognize a family of self-induced stress ligands that are upregulated on stressed cells such as cancerous or virally infected cells. Fungal pathogens are a major threat to human health, infecting more than a billion patients yearly and becoming more common and drug resistant. Here we show that NKG2D plays a critical role in the immune response against fungal infections. NKG2D can recognize fungal pathogens from most major families including Candida, Cryptococcus and Aspergillus species, and mice lacking NKG2D are extremely sensitive to fungal infections in models of both invasive and mucosal infections, making NKG2D an anti-fungal pattern recognition receptor.
UR - http://www.scopus.com/inward/record.url?scp=85205776261&partnerID=8YFLogxK
U2 - 10.1038/s41467-024-52913-2
DO - 10.1038/s41467-024-52913-2
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C2 - 39375344
AN - SCOPUS:85205776261
SN - 2041-1723
VL - 15
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 8664
ER -