The accuracy of serum interleukin-6 and tumour necrosis factor as markers for ovarian torsion

Shlomo B. Cohen*, Arnaud Wattiez, David Stockheim, Daniel S. Seidman, Arie L. Lidor, Shlomo Mashiach, Mordechai Goldenberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Background: The aim of this study was to investigate a possible role for interleukin-6 (IL-6) and tumour necrosis factor (TNF-α) as pre-operative markers for the diagnosis of ovarian torsion. Methods: Twenty consecutive patients admitted to the gynaecological emergency room with suspected clinical diagnosis of ovarian torsion were prospectively assigned to the study. Blood samples were drawn pre-operatively and examined for serum concentrations of IL-6 and TNF-α. Surgeons were blinded to laboratory results prior to laparoscopy. Results: The pre-operative diagnosis of ovarian torsion was confirmed during an urgent diagnostic laparoscopy in 8 (40%) patients. The surgical diagnosis among the remaining 12 patients was a large ovarian cyst not in torsion. In six out of eight (75.0%) patients with ovarian torsion serum IL-6 concentrations were elevated. None of the 12 patients without torsion had elevated serum IL-6 concentrations. This difference was statistically significant (P < 0.001). There was no significant difference in the proportion of women with elevated serum TNF-α concentrations, two of eight (25.0%) patients with torsion and four of 12 (33.3%) control cases. Conclusions: Elevated serum IL-6 concentrations, but not serum TNF-α concentrations, were significantly associated with the occurrence of ovarian torsion. In patients with vague clinical signs of ovarian torsion, serum IL-6 might help to distinguish which patients should undergo diagnostic laparoscopy.

Original languageEnglish
Pages (from-to)2195-2197
Number of pages3
JournalHuman Reproduction
Issue number10
StatePublished - 2001
Externally publishedYes


  • Interleukin-6
  • Markers
  • Ovarian torsion
  • Tumour necrosis factor-α


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