The μ-opioid receptor nonsynonymous variant 118A>G is associated with prolonged abstinence from heroin without agonist treatment

Orna Levran, Einat Peles, Matthew Randesi, Joel Correa Da Rosa, Miriam Adelson, Mary Jeanne Kreek

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: This study assesses whether opioid-related gene variants contribute to reduced vulnerability to relapse to heroin in persons who are not treated with μ-opioid receptor agonist. Methods: Genotypes of 71 SNPs, in nine genes, were analyzed for association with long-term abstinence in former heroin-dependents of European/Middle Eastern ancestry, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 922). Results: The functional OPRM1 nonsynonymous SNP rs1799971 (118A>G) showed significant association with long-term abstinence (Ppermutation = 0.03, dominant model, OR: 2.2; 95% CI: 1.5-3.3). Conclusion: Since the stress axis is regulated in part by β-endorphin, this functional OPRM1 SNP may blunt the endogenous stress response and contribute to reduced vulnerability for relapse.

Original languageEnglish
Pages (from-to)1393-1400
Number of pages8
JournalPharmacogenomics
Volume18
Issue number15
DOIs
StatePublished - Oct 2017

Keywords

  • abstinence
  • heroin addiction
  • HPA axis
  • opioids
  • rs1799971
  • stress
  • μ-opioid receptor

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