The μ-opioid receptor nonsynonymous variant 118A>G is associated with prolonged abstinence from heroin without agonist treatment

Orna Levran; Einat Peles; Matthew Randesi; Joel Correa Da Rosa; Miriam Adelson; Mary Jeanne Kreek

doi:10.2217/pgs-2017-0092

The μ-opioid receptor nonsynonymous variant 118A>G is associated with prolonged abstinence from heroin without agonist treatment

Orna Levran, Einat Peles, Matthew Randesi, Joel Correa Da Rosa, Miriam Adelson, Mary Jeanne Kreek

Clinical Departments

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: This study assesses whether opioid-related gene variants contribute to reduced vulnerability to relapse to heroin in persons who are not treated with μ-opioid receptor agonist. Methods: Genotypes of 71 SNPs, in nine genes, were analyzed for association with long-term abstinence in former heroin-dependents of European/Middle Eastern ancestry, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 922). Results: The functional OPRM1 nonsynonymous SNP rs1799971 (118A>G) showed significant association with long-term abstinence (P_permutation = 0.03, dominant model, OR: 2.2; 95% CI: 1.5-3.3). Conclusion: Since the stress axis is regulated in part by β-endorphin, this functional OPRM1 SNP may blunt the endogenous stress response and contribute to reduced vulnerability for relapse.

Original language	English
Pages (from-to)	1393-1400
Number of pages	8
Journal	Pharmacogenomics
Volume	18
Issue number	15
DOIs	https://doi.org/10.2217/pgs-2017-0092
State	Published - Oct 2017

Keywords

abstinence
heroin addiction
HPA axis
opioids
rs1799971
stress
μ-opioid receptor

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title = "The μ-opioid receptor nonsynonymous variant 118A>G is associated with prolonged abstinence from heroin without agonist treatment",

abstract = "Aim: This study assesses whether opioid-related gene variants contribute to reduced vulnerability to relapse to heroin in persons who are not treated with μ-opioid receptor agonist. Methods: Genotypes of 71 SNPs, in nine genes, were analyzed for association with long-term abstinence in former heroin-dependents of European/Middle Eastern ancestry, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 922). Results: The functional OPRM1 nonsynonymous SNP rs1799971 (118A>G) showed significant association with long-term abstinence (Ppermutation = 0.03, dominant model, OR: 2.2; 95% CI: 1.5-3.3). Conclusion: Since the stress axis is regulated in part by β-endorphin, this functional OPRM1 SNP may blunt the endogenous stress response and contribute to reduced vulnerability for relapse.",

keywords = "abstinence, heroin addiction, HPA axis, opioids, rs1799971, stress, μ-opioid receptor",

author = "Orna Levran and Einat Peles and Matthew Randesi and {Da Rosa}, {Joel Correa} and Miriam Adelson and Kreek, {Mary Jeanne}",

note = "Publisher Copyright: {\textcopyright} 2017 Future Medicine Ltd.",

year = "2017",

month = oct,

doi = "10.2217/pgs-2017-0092",

language = "אנגלית",

volume = "18",

pages = "1393--1400",

journal = "Pharmacogenomics",

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T1 - The μ-opioid receptor nonsynonymous variant 118A>G is associated with prolonged abstinence from heroin without agonist treatment

AU - Levran, Orna

AU - Peles, Einat

AU - Randesi, Matthew

AU - Da Rosa, Joel Correa

AU - Adelson, Miriam

AU - Kreek, Mary Jeanne

PY - 2017/10

Y1 - 2017/10

N2 - Aim: This study assesses whether opioid-related gene variants contribute to reduced vulnerability to relapse to heroin in persons who are not treated with μ-opioid receptor agonist. Methods: Genotypes of 71 SNPs, in nine genes, were analyzed for association with long-term abstinence in former heroin-dependents of European/Middle Eastern ancestry, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 922). Results: The functional OPRM1 nonsynonymous SNP rs1799971 (118A>G) showed significant association with long-term abstinence (Ppermutation = 0.03, dominant model, OR: 2.2; 95% CI: 1.5-3.3). Conclusion: Since the stress axis is regulated in part by β-endorphin, this functional OPRM1 SNP may blunt the endogenous stress response and contribute to reduced vulnerability for relapse.

AB - Aim: This study assesses whether opioid-related gene variants contribute to reduced vulnerability to relapse to heroin in persons who are not treated with μ-opioid receptor agonist. Methods: Genotypes of 71 SNPs, in nine genes, were analyzed for association with long-term abstinence in former heroin-dependents of European/Middle Eastern ancestry, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 922). Results: The functional OPRM1 nonsynonymous SNP rs1799971 (118A>G) showed significant association with long-term abstinence (Ppermutation = 0.03, dominant model, OR: 2.2; 95% CI: 1.5-3.3). Conclusion: Since the stress axis is regulated in part by β-endorphin, this functional OPRM1 SNP may blunt the endogenous stress response and contribute to reduced vulnerability for relapse.

KW - abstinence

KW - heroin addiction

KW - HPA axis

KW - opioids

KW - rs1799971

KW - stress

KW - μ-opioid receptor

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JO - Pharmacogenomics

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IS - 15

ER -

The μ-opioid receptor nonsynonymous variant 118A>G is associated with prolonged abstinence from heroin without agonist treatment

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