TY - JOUR
T1 - Thalamic stimulation for parkinsonian tremor
T2 - Correlation between regional cerebral blood flow and physiological tremor characteristics
AU - Fukuda, Masafumi
AU - Barnes, Anna
AU - Simon, Ely S.
AU - Holmes, Andrew
AU - Dhawan, Vijay
AU - Giladi, Nir
AU - Fodstad, Harald
AU - Ma, Yilong
AU - Eidelberg, David
N1 - Funding Information:
This work was supported by NIH NS RO1 35069 (D.E.). Dr. Eidelberg was supported by NIH K24 NS 02101. Dr. Fukuda was supported by the Veola T. Kerr Fellowship of the Parkinson Disease Foundation. The authors wish to thank Dr. Thomas Chaly for radiochemistry support and Ms. Loreta Palazzo for editorial assistance. We acknowledge the valuable technical support provided by Dr. Abdel Belakhleff, Mr. Claude Margouleff, and Mr. Ralph Mattachieri.
PY - 2004/2
Y1 - 2004/2
N2 - We used 15O-labeled water (H215O) positron emission tomography (PET) to study eight Parkinson's disease (PD) patients with unilateral ventral intermediate (Vim) thalamic nucleus deep brain stimulation (DBS) for severe tremor. Triaxial accelerometry (TRIAX) was used during imaging to obtain on-line measures of tremor characteristics. Regional cerebral blood flow (rCBF) scans together with TRIAX recordings were collected in three stimulation conditions (OFF, MID, and ON, corresponding, respectively, to 0%, 50%, and 100% reductions in mean accelerometry signal). Statistical Parametric Mapping (SPM99) revealed significant rCBF reductions during stimulation in the ipsilateral sensorimotor cortex (SMC) and the contralateral cerebellum, as well as concurrent increases in the ipsilateral ventral thalamus (P < 0.05, corrected). Covariate analysis of rCBF with physiological tremor characteristics revealed that tremor acceleration correlated positively with changes in the SMC and supplementary motor cortex ipsilaterally (P < 0.05, uncorrected), and negatively with changes in the ipsilateral cuneus (P < 0.05, corrected). After removing tremor acceleration effects, changes in tremor frequency correlated negatively with changes in the contralateral dentate nucleus and pons (P < 0.05, uncorrected). Our results suggest that Vim DBS for PD tremor modulates the activity of cerebello-thalamo-cortical pathways. Specific tremor characteristics relate to activity in different nodes of this system.
AB - We used 15O-labeled water (H215O) positron emission tomography (PET) to study eight Parkinson's disease (PD) patients with unilateral ventral intermediate (Vim) thalamic nucleus deep brain stimulation (DBS) for severe tremor. Triaxial accelerometry (TRIAX) was used during imaging to obtain on-line measures of tremor characteristics. Regional cerebral blood flow (rCBF) scans together with TRIAX recordings were collected in three stimulation conditions (OFF, MID, and ON, corresponding, respectively, to 0%, 50%, and 100% reductions in mean accelerometry signal). Statistical Parametric Mapping (SPM99) revealed significant rCBF reductions during stimulation in the ipsilateral sensorimotor cortex (SMC) and the contralateral cerebellum, as well as concurrent increases in the ipsilateral ventral thalamus (P < 0.05, corrected). Covariate analysis of rCBF with physiological tremor characteristics revealed that tremor acceleration correlated positively with changes in the SMC and supplementary motor cortex ipsilaterally (P < 0.05, uncorrected), and negatively with changes in the ipsilateral cuneus (P < 0.05, corrected). After removing tremor acceleration effects, changes in tremor frequency correlated negatively with changes in the contralateral dentate nucleus and pons (P < 0.05, uncorrected). Our results suggest that Vim DBS for PD tremor modulates the activity of cerebello-thalamo-cortical pathways. Specific tremor characteristics relate to activity in different nodes of this system.
KW - Anti-Aβ
KW - Cerebral blood flow
KW - Parkinson's disease
UR - http://www.scopus.com/inward/record.url?scp=1242271381&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2003.09.068
DO - 10.1016/j.neuroimage.2003.09.068
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C2 - 14980563
AN - SCOPUS:1242271381
SN - 1053-8119
VL - 21
SP - 608
EP - 615
JO - NeuroImage
JF - NeuroImage
IS - 2
ER -