Tetrada of the possible mycophenolate mofetil embryopathy: A review

Paul Merlob*, Bracha Stahl, Gil Klinger

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Mycophenolate mofetil (MFM) is an immunosuppressant agent used in organ transplantation, rheumatoid arthritis and lupus nephritis. Experimental data show that doses roughly equivalent to those used clinically in transplant patients may cause fetal resorption and malformations in pregnant rats and rabbits. There are limited data regarding the use of MFM in pregnant women. The human experience is based on 9 case reports, 1 case series, and 2 registry data. The most frequent structural anomalies described in 12 newborns exposed to MFM were as follows: microtia (11); auditory canal atresia (8); cleft lip and palate (6); micrognathia (4); hypertelorism (4); ocular coloboma (3); short fingers (2) and hypoplasic nails (2). The distinctive and unique phenotype associated with MFM exposure during pregnancy (EMFO tetrada: Ear, Mouth, Fingers, Ocular/Organ malformation) raised the hypothesis that MFM may be a real teratogenic drug. Appropriate recommendations to prevent this possible new embryopathy are given.

Original languageEnglish
Pages (from-to)105-108
Number of pages4
JournalReproductive Toxicology
Volume28
Issue number1
DOIs
StatePublished - Jul 2009
Externally publishedYes

Keywords

  • Embryopathy
  • Immunosuppressant drugs
  • Malformations
  • Teratogen
  • Toxicology

Fingerprint

Dive into the research topics of 'Tetrada of the possible mycophenolate mofetil embryopathy: A review'. Together they form a unique fingerprint.

Cite this