Testicular sperm retrieval and intra cytoplasmic sperm injection provide favorable outcome in spinal cord injury patients, failing conservative reproductive treatment

G. Raviv*, I. Madgar, S. Elizur, G. Zeilig, J. Levron

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Study design:Retrospective cohort analysis.Objectives:The objective of this study was to determine the in vitro fertilization (IVF) outcome after testicular sperm extraction (TESE) in a group of spinal cord injury (SCI) male patients not compatible with conservative fertility treatment.Setting: University-affiliated medical center.Methods:Thirty two SCI patients (C2 to L2) were referred to IVF after repeated trials of electroejaculation (EEJ) or penile vibratory stimulation (PVS), and full andrological evaluation. Testicular sperm aspiration (TESA) was the method of choice for sperm extraction. Open TESE was performed only after a negative TESA attempt. Clinical pregnancy and live birth rates were determined.Results:A total of 106 testicular procedures were performed. Sperm was found in 95 cycles (89.6%). The average metaphase II (MII) oocyte number was 11.0±4.2, an average of 5.1±2.3 oocytes became normally fertilized after Intra Cytoplasmic Sperm Injection (ICSI) (fertilization rate 57.1%). On average, 2.7±1.2 embryos were replaced. The clinical pregnancy rate was 32/106 (30.2%) per cycle and 19/32 (59.3%) per couple. Live birth rate was 62.5% (20/32).Conclusions:TESA/E and IVF can provide excellent prognosis for SCI patients that cannot be treated by EEJ or PVS.

Original languageEnglish
Pages (from-to)642-644
Number of pages3
JournalSpinal Cord
Volume51
Issue number8
DOIs
StatePublished - Aug 2013

Keywords

  • in vitro fertilization
  • spinal cord injury
  • testicular sperm extraction

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