Testicular Seminoma: Clinical Significance of Nuclear Deoxyribonucleic Acid Ploidy Pattern as Studied by Flow Cytometry

Yoram Mor, Ilan Leibovich, Gil Raviv, Devora Nass, Ora Medalia, Benad Goldwasser, Ofer Nativ

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: We evaluated the clinical significance of deoxyribonucleic acid (DNA) ploidy pattern as a predictor of prognosis in patients with testicular seminoma. Materials and Methods: Flow cytometric nuclear DNA analysis was performed on archival specimens from 65 patients with pure seminoma who underwent radical orchiectomy between 1970 and 1992. Results: A total of 42 specimens (65 percent) exhibited a DNA diploid pattern, while 23 (35 percent) were DNA aneuploid. Diploidy was manifested in 73 percent of the stage I tumors versus 31 percent of stage II cancers (p = 0.004). No correlation was found between ploidy and histological type, size or local extension of the tumor. Tumor progression was observed in 5 patients, exclusively displaying aneuploid histograms (p = 0.0017), and 3 of them subsequently died of the disease. Conclusions: DNA ploidy pattern may provide important prognostic information for patients with testicular seminoma.

Original languageEnglish
Pages (from-to)1041-1044
Number of pages4
JournalJournal of Urology
Volume154
Issue number3
DOIs
StatePublished - Sep 1995
Externally publishedYes

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