Testicular Seminoma: Clinical Significance of Nuclear Deoxyribonucleic Acid Ploidy Pattern as Studied by Flow Cytometry

Yoram Mor; Ilan Leibovich; Gil Raviv; Devora Nass; Ora Medalia; Benad Goldwasser; Ofer Nativ

doi:10.1016/S0022-5347(01)66970-2

Testicular Seminoma: Clinical Significance of Nuclear Deoxyribonucleic Acid Ploidy Pattern as Studied by Flow Cytometry

Yoram Mor, Ilan Leibovich, Gil Raviv, Devora Nass, Ora Medalia, Benad Goldwasser, Ofer Nativ

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: We evaluated the clinical significance of deoxyribonucleic acid (DNA) ploidy pattern as a predictor of prognosis in patients with testicular seminoma. Materials and Methods: Flow cytometric nuclear DNA analysis was performed on archival specimens from 65 patients with pure seminoma who underwent radical orchiectomy between 1970 and 1992. Results: A total of 42 specimens (65 percent) exhibited a DNA diploid pattern, while 23 (35 percent) were DNA aneuploid. Diploidy was manifested in 73 percent of the stage I tumors versus 31 percent of stage II cancers (p = 0.004). No correlation was found between ploidy and histological type, size or local extension of the tumor. Tumor progression was observed in 5 patients, exclusively displaying aneuploid histograms (p = 0.0017), and 3 of them subsequently died of the disease. Conclusions: DNA ploidy pattern may provide important prognostic information for patients with testicular seminoma.

Original language	English
Pages (from-to)	1041-1044
Number of pages	4
Journal	Journal of Urology
Volume	154
Issue number	3
DOIs	https://doi.org/10.1016/S0022-5347(01)66970-2
State	Published - Sep 1995
Externally published	Yes

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10.1016/S0022-5347(01)66970-2

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title = "Testicular Seminoma: Clinical Significance of Nuclear Deoxyribonucleic Acid Ploidy Pattern as Studied by Flow Cytometry",

abstract = "Purpose: We evaluated the clinical significance of deoxyribonucleic acid (DNA) ploidy pattern as a predictor of prognosis in patients with testicular seminoma. Materials and Methods: Flow cytometric nuclear DNA analysis was performed on archival specimens from 65 patients with pure seminoma who underwent radical orchiectomy between 1970 and 1992. Results: A total of 42 specimens (65 percent) exhibited a DNA diploid pattern, while 23 (35 percent) were DNA aneuploid. Diploidy was manifested in 73 percent of the stage I tumors versus 31 percent of stage II cancers (p = 0.004). No correlation was found between ploidy and histological type, size or local extension of the tumor. Tumor progression was observed in 5 patients, exclusively displaying aneuploid histograms (p = 0.0017), and 3 of them subsequently died of the disease. Conclusions: DNA ploidy pattern may provide important prognostic information for patients with testicular seminoma.",

author = "Yoram Mor and Ilan Leibovich and Gil Raviv and Devora Nass and Ora Medalia and Benad Goldwasser and Ofer Nativ",

year = "1995",

month = sep,

doi = "10.1016/S0022-5347(01)66970-2",

language = "אנגלית",

volume = "154",

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journal = "Journal of Urology",

issn = "0022-5347",

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number = "3",

}

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T1 - Testicular Seminoma

T2 - Clinical Significance of Nuclear Deoxyribonucleic Acid Ploidy Pattern as Studied by Flow Cytometry

AU - Mor, Yoram

AU - Leibovich, Ilan

AU - Raviv, Gil

AU - Nass, Devora

AU - Medalia, Ora

AU - Goldwasser, Benad

AU - Nativ, Ofer

PY - 1995/9

Y1 - 1995/9

N2 - Purpose: We evaluated the clinical significance of deoxyribonucleic acid (DNA) ploidy pattern as a predictor of prognosis in patients with testicular seminoma. Materials and Methods: Flow cytometric nuclear DNA analysis was performed on archival specimens from 65 patients with pure seminoma who underwent radical orchiectomy between 1970 and 1992. Results: A total of 42 specimens (65 percent) exhibited a DNA diploid pattern, while 23 (35 percent) were DNA aneuploid. Diploidy was manifested in 73 percent of the stage I tumors versus 31 percent of stage II cancers (p = 0.004). No correlation was found between ploidy and histological type, size or local extension of the tumor. Tumor progression was observed in 5 patients, exclusively displaying aneuploid histograms (p = 0.0017), and 3 of them subsequently died of the disease. Conclusions: DNA ploidy pattern may provide important prognostic information for patients with testicular seminoma.

AB - Purpose: We evaluated the clinical significance of deoxyribonucleic acid (DNA) ploidy pattern as a predictor of prognosis in patients with testicular seminoma. Materials and Methods: Flow cytometric nuclear DNA analysis was performed on archival specimens from 65 patients with pure seminoma who underwent radical orchiectomy between 1970 and 1992. Results: A total of 42 specimens (65 percent) exhibited a DNA diploid pattern, while 23 (35 percent) were DNA aneuploid. Diploidy was manifested in 73 percent of the stage I tumors versus 31 percent of stage II cancers (p = 0.004). No correlation was found between ploidy and histological type, size or local extension of the tumor. Tumor progression was observed in 5 patients, exclusively displaying aneuploid histograms (p = 0.0017), and 3 of them subsequently died of the disease. Conclusions: DNA ploidy pattern may provide important prognostic information for patients with testicular seminoma.

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Testicular Seminoma: Clinical Significance of Nuclear Deoxyribonucleic Acid Ploidy Pattern as Studied by Flow Cytometry

Abstract

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