Test of a Retinal Nerve Fiber Bundle Trajectory Model Using Eyes With Glaucomatous Optic Neuropathy

Zane Zenon Zemborain, Emmanouil Tsamis, Sol La Bruna, Ari Leshno, Carlos Gustavo De Moraes, Donald Charles Hood*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Purpose: To test a model of retinal nerve fiber bundle trajectories that predicts the arcuate-shaped patterns seen on optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) probability/deviation maps (p-maps) in glaucomatous eyes. Methods: Thirty-one glaucomatous eyes from a database of 250 eyes had clear arcuate-shaped patterns on RNFL p-maps derived from an OCT cube scan. The borders of the arcuate patterns were extracted from the RNFL p-maps. Next, the trajectories from an arcuate model were compared against these borders via a normalized root-mean-square difference analysis. The model’s parameter, β, was varied, and the best-fitting, initial clock-hour position of the trajectory to the border was found for each β. Finally,the regions, as determined by the arcuate border’s best-fit, initial clock-hour positions, were compared against the abnormal regions on the circumpapillary retinal nerve fiber layer (cpRNFL) profile. Results: The arcuate model’s mean βSup and βInf parameters minimized large differences between the trajectories and the arcuate borders on the RNFL p-maps. Furthermore, on average, 68% of the cpRNFL regions defined by the arcuate border’s best-fit, initial clock-hour positions were abnormal (i.e., below the ≤5% threshold). Conclusions: The arcuate model performed well in predicting the borders of arcuate patterns seen on RNFL p-maps. It also predicted the associated abnormal regions of the cpRNFL thickness plots. Translational Relevance: This model should prove useful in helping clinicians under-stand topographical comparisons among different OCT representations and should improve structure-structure, as well as structure-function agreement analyses.

Original languageEnglish
Article number7
JournalTranslational Vision Science and Technology
Issue number7
StatePublished - Jul 2022


  • Arcuate
  • Glaucoma
  • Optical Coherence Tomography


Dive into the research topics of 'Test of a Retinal Nerve Fiber Bundle Trajectory Model Using Eyes With Glaucomatous Optic Neuropathy'. Together they form a unique fingerprint.

Cite this