Temporal trends in patient characteristics and survival of intensive care admissions with sepsis: A multicenter analysis*

Jacob Dreiher, Yaniv Almog, Charles L. Sprung, Shlomi Codish, Moti Klein, Sharon Einav, Yaron Bar-Lavie, Pierre P. Singer, Adi Nimrod, Jeffrey Sachs, Daniel Talmor, Michael Friger, Dan Greenberg, David Olsfanger, Moshe Hersch, Victor Novack*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


OBJECTIVE: To estimate in-hospital, 1-yr, and long-term mortality and to assess time trends in incidence and outcomes of sepsis admissions in the intensive care unit. DESIGN: A population-based, multicenter, retrospective cohort study. PATIENTS: Patients hospitalized with sepsis in the intensive care unit in seven general hospitals in Israel during 2002-2008. INTERVENTIONS: None. MEASUREMENTS: Survival data were collected and analyzed according to demographic and background clinical characteristics, as well as features of the sepsis episode, using Kaplan-Meier approach for long-term survival. MAIN RESULTS: A total of 5,155 patients were included in the cohort (median age: 70, 56.3% males; median Charlson comorbidity index: 4). The mean number of intensive care unit admissions per month increased over time, while no change in in-hospital mortality was observed. The proportion of patients surviving to hospital discharge was 43.9%. The 1-, 2-, 5-, and 8-yr survival rates were 33.0%, 29.8%, 23.3%, and 19.8%, respectively. Mortality was higher in older patients, patients with a higher Charlson comorbidity index, and those with multiorgan failure, and similar in males and females. One-year age-standardized mortality ratio was 21-fold higher than expected, based on the general population rates. CONCLUSIONS: Mortality following intensive care unit sepsis admission remains high and is correlated with underlying patients' characteristics, including age, comorbidities, and the number of failing organ systems.

Original languageEnglish
Pages (from-to)855-860
Number of pages6
JournalCritical Care Medicine
Issue number3
StatePublished - Mar 2012
Externally publishedYes


  • intensive care
  • long-term survival
  • mortality
  • outcome assessment
  • sepsis
  • septic shock


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