Temporal patterns selection for All-Cause Mortality prediction in T2D with ANNs

Pavel Novitski*, Cheli Melzer Cohen, Avraham Karasik, Gabriel Hodik, Robert Moskovitch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Mortality prevention in T2D elderly population having Chronic Kidney Disease (CKD) may be possible thorough risk assessment and predictive modeling. In this study we investigate the ability to predict mortality using heterogeneous Electronic Health Records data. Temporal abstraction is employed to transform the heterogeneous multivariate temporal data into a uniform representation of symbolic time intervals, from which then frequent Time Intervals Related Patterns (TIRPs) are discovered. However, in this study a novel representation of the TIRPs is introduced, which enables to incorporate them in Deep Learning Networks. We describe here the use of iTirps and bTirps, in which the TIRPs are represented by a integer and binary vector representing the time respectively. While bTirp represents whether a TIRP's instance was present, iTirp represents whether multiple instances were present. While the framework showed encouraging results, a major challenge is often the large number of TIRPs, which may cause the models to under-perform. We introduce a novel method for TIRPs’ selection method, called TIRP Ranking Criteria (TRC), which is consists on the TIRP's metrics, such as the differences in its recurrences, its frequencies, and the average duration difference between the classes. Additionally, we introduce an advanced version, called TRC Redundant TIRP Removal (TRC-RTR), TIRPs that highly correlate are candidates for removal. Then the selected subset of iTirp/bTirps is fed into a Deep Learning architecture like a Recurrent Neural Network or a Convolutional Neural Network. Furthermore, a predictive committee is utilized in which raw data and iTirp data are both used as input. Our results show that iTirps-based models that use a subset of iTirps based on the TRC-RTR method outperform models that use raw data or models that use full set of discovered iTirps.

Original languageEnglish
Article number104198
JournalJournal of Biomedical Informatics
StatePublished - Oct 2022
Externally publishedYes


FundersFunder number
Ministry of Science and Technology, Israel8760521


    • Deep learning
    • Pattern mining
    • Temporal data prediction


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