TY - JOUR
T1 - Temperature-dependent proteolysis as a control element in Escherichia coli metabolism
AU - Katz, Chen
AU - Rasouly, Aviram
AU - Gur, Eyal
AU - Shenhar, Yotam
AU - Biran, Dvora
AU - Ron, Eliora Z.
PY - 2009/11
Y1 - 2009/11
N2 - Escherichia coli can grow at a broad temperature range, from less than 20 °C up to 45 °C. An increase in temperature results in a major physiological change, as enzymes work faster but, on the other hand, proteins tend to unfold. Therefore, a shift-up in temperature results in the induction of several regulatory response mechanisms aimed at restoring balanced growth at the new temperature. One important mechanism involves temperature-dependent proteolysis, which constitutes a fast response to temperature shift-ups. Here we discuss the effect of proteolysis on protein synthesis, and the heat shock response.
AB - Escherichia coli can grow at a broad temperature range, from less than 20 °C up to 45 °C. An increase in temperature results in a major physiological change, as enzymes work faster but, on the other hand, proteins tend to unfold. Therefore, a shift-up in temperature results in the induction of several regulatory response mechanisms aimed at restoring balanced growth at the new temperature. One important mechanism involves temperature-dependent proteolysis, which constitutes a fast response to temperature shift-ups. Here we discuss the effect of proteolysis on protein synthesis, and the heat shock response.
KW - Heat shock response
KW - Methionine biosynthesis
KW - Protein degradation
UR - https://www.scopus.com/pages/publications/71749092092
U2 - 10.1016/j.resmic.2009.08.015
DO - 10.1016/j.resmic.2009.08.015
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AN - SCOPUS:71749092092
SN - 0923-2508
VL - 160
SP - 684
EP - 686
JO - Research in Microbiology
JF - Research in Microbiology
IS - 9
ER -