TY - JOUR
T1 - Telomere capture in hepatitis C infection
AU - Goldberg-Bittman, Lilach
AU - Amiel, Aliza
AU - Hadary, Ruth
AU - Fejgin, Moshe D.
AU - Quitt, Miriam
AU - Kitay-Cohen, Yona
N1 - Funding Information:
This work was done with the help of a grant from the Israel Cancer Association (RA).
PY - 2009/6
Y1 - 2009/6
N2 - Broken chromosomes can acquire new telomeres by "telomere capture" (TC), and it has become possible to investigate the terminus in cytogenetically visible telomere rearrangements. The TC phenomenon was observed in malignant conditions. We evaluated the TC rate in hepatitis C virus (HCV) patients compared to non-Hodgkin's lymphoma patients, as well as relative to a control group. For this purpose, we used two Cytocell probes, 15qter and 13qter. Higher TC rates were found in the three study groups relative to the control group. Our results showed that HCV patients have some of the components that can initiate the cascade of events leading to malignancies.
AB - Broken chromosomes can acquire new telomeres by "telomere capture" (TC), and it has become possible to investigate the terminus in cytogenetically visible telomere rearrangements. The TC phenomenon was observed in malignant conditions. We evaluated the TC rate in hepatitis C virus (HCV) patients compared to non-Hodgkin's lymphoma patients, as well as relative to a control group. For this purpose, we used two Cytocell probes, 15qter and 13qter. Higher TC rates were found in the three study groups relative to the control group. Our results showed that HCV patients have some of the components that can initiate the cascade of events leading to malignancies.
UR - http://www.scopus.com/inward/record.url?scp=65549142163&partnerID=8YFLogxK
U2 - 10.1016/j.cancergencyto.2009.01.013
DO - 10.1016/j.cancergencyto.2009.01.013
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AN - SCOPUS:65549142163
SN - 0165-4608
VL - 191
SP - 63
EP - 66
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -
