Telomere capture in hepatitis C infection

Lilach Goldberg-Bittman, Aliza Amiel*, Ruth Hadary, Moshe D. Fejgin, Miriam Quitt, Yona Kitay-Cohen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Broken chromosomes can acquire new telomeres by "telomere capture" (TC), and it has become possible to investigate the terminus in cytogenetically visible telomere rearrangements. The TC phenomenon was observed in malignant conditions. We evaluated the TC rate in hepatitis C virus (HCV) patients compared to non-Hodgkin's lymphoma patients, as well as relative to a control group. For this purpose, we used two Cytocell probes, 15qter and 13qter. Higher TC rates were found in the three study groups relative to the control group. Our results showed that HCV patients have some of the components that can initiate the cascade of events leading to malignancies.

Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalCancer Genetics and Cytogenetics
Issue number2
StatePublished - Jun 2009


FundersFunder number
Israel Cancer Association


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