Telomere aggregates in hepatitis C patients

A. Amiel*, M. D. Fejgin, L. Goldberg-Bittman, R. Sharoni, R. Hadary, Y. Kitay-Cohen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Telomeres of tumor nuclei tend to form aggregates (TA). The aim of this study was to estimate the TA formation in leukocytes of patients with chronic hepatitis C (HCV) which is considered to be premalignant disease, in patients of HCV who eradicated the virus. PNA Telomere kit (Dako) was used to evaluate the TA formation with the utilization of 2D fluorescence microscopy. A higher rate of TA was found in both HCV groups as compared to controls. Our results indicate that HCV patients have some of the components that create the cascade of events leading to malignancies.

Original languageEnglish
Pages (from-to)650-654
Number of pages5
JournalCancer Investigation
Issue number6
StatePublished - Jul 2009


  • Cancer genetics
  • Detection/Diagnosis
  • Liver and biliary system


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