Telomere aggregates in hepatitis C patients

A. Amiel; M. D. Fejgin; L. Goldberg-Bittman; R. Sharoni; R. Hadary; Y. Kitay-Cohen

doi:10.1080/07357900802350806

Telomere aggregates in hepatitis C patients

A. Amiel^*, M. D. Fejgin, L. Goldberg-Bittman, R. Sharoni, R. Hadary, Y. Kitay-Cohen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Telomeres of tumor nuclei tend to form aggregates (TA). The aim of this study was to estimate the TA formation in leukocytes of patients with chronic hepatitis C (HCV) which is considered to be premalignant disease, in patients of HCV who eradicated the virus. PNA Telomere kit (Dako) was used to evaluate the TA formation with the utilization of 2D fluorescence microscopy. A higher rate of TA was found in both HCV groups as compared to controls. Our results indicate that HCV patients have some of the components that create the cascade of events leading to malignancies.

Original language	English
Pages (from-to)	650-654
Number of pages	5
Journal	Cancer Investigation
Volume	27
Issue number	6
DOIs	https://doi.org/10.1080/07357900802350806
State	Published - Jul 2009

Keywords

Cancer genetics
Detection/Diagnosis
Liver and biliary system

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/07357900802350806

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title = "Telomere aggregates in hepatitis C patients",

abstract = "Telomeres of tumor nuclei tend to form aggregates (TA). The aim of this study was to estimate the TA formation in leukocytes of patients with chronic hepatitis C (HCV) which is considered to be premalignant disease, in patients of HCV who eradicated the virus. PNA Telomere kit (Dako) was used to evaluate the TA formation with the utilization of 2D fluorescence microscopy. A higher rate of TA was found in both HCV groups as compared to controls. Our results indicate that HCV patients have some of the components that create the cascade of events leading to malignancies.",

keywords = "Cancer genetics, Detection/Diagnosis, Liver and biliary system",

author = "A. Amiel and Fejgin, {M. D.} and L. Goldberg-Bittman and R. Sharoni and R. Hadary and Y. Kitay-Cohen",

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AU - Amiel, A.

AU - Fejgin, M. D.

AU - Goldberg-Bittman, L.

AU - Sharoni, R.

AU - Hadary, R.

AU - Kitay-Cohen, Y.

PY - 2009/7

Y1 - 2009/7

N2 - Telomeres of tumor nuclei tend to form aggregates (TA). The aim of this study was to estimate the TA formation in leukocytes of patients with chronic hepatitis C (HCV) which is considered to be premalignant disease, in patients of HCV who eradicated the virus. PNA Telomere kit (Dako) was used to evaluate the TA formation with the utilization of 2D fluorescence microscopy. A higher rate of TA was found in both HCV groups as compared to controls. Our results indicate that HCV patients have some of the components that create the cascade of events leading to malignancies.

AB - Telomeres of tumor nuclei tend to form aggregates (TA). The aim of this study was to estimate the TA formation in leukocytes of patients with chronic hepatitis C (HCV) which is considered to be premalignant disease, in patients of HCV who eradicated the virus. PNA Telomere kit (Dako) was used to evaluate the TA formation with the utilization of 2D fluorescence microscopy. A higher rate of TA was found in both HCV groups as compared to controls. Our results indicate that HCV patients have some of the components that create the cascade of events leading to malignancies.

KW - Cancer genetics

KW - Detection/Diagnosis

KW - Liver and biliary system

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VL - 27

SP - 650

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JO - Cancer Investigation

JF - Cancer Investigation

IS - 6

ER -

Telomere aggregates in hepatitis C patients

Abstract

Keywords

UN SDGs

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