Tausalarin C: A new bioactive marine sponge-derived nitrogenous bismacrolide

Ashgan Bishara, Amira Rudi, Israel Goldberg, Maurice Aknin, Drorit Neumann, Nathalie Ben-Califa, Yoel Kashman

Research output: Contribution to journalArticlepeer-review

Abstract

Image Persented A novel nitrogenous bismacrolide, designated tausalarin C (1), was isolated from the Madagascar sponge Fascaplysinopsis sp. The structure of the compound was elucidated by interpretation of MS and 1D and 2D NMR spectra. It is suggested that tausalarin C is assembled from salarin A (2) and pretaumycin A. The relative configuration of the chiral centers of salarin A was determined by X-ray diffraction. Tausalarin C was found to inhibit proliferation of K562 leukemia cells. A possible biogenesis is discussed.

Original languageEnglish
Pages (from-to)3538-3541
Number of pages4
JournalOrganic Letters
Volume11
Issue number16
DOIs
StatePublished - 20 Aug 2009

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