Tausalarin C: A new bioactive marine sponge-derived nitrogenous bismacrolide

Ashgan Bishara; Amira Rudi; Israel Goldberg; Maurice Aknin; Drorit Neumann; Nathalie Ben-Califa; Yoel Kashman

doi:10.1021/ol9011019

Tausalarin C: A new bioactive marine sponge-derived nitrogenous bismacrolide

Ashgan Bishara^*, Amira Rudi, Israel Goldberg, Maurice Aknin, Drorit Neumann, Nathalie Ben-Califa, Yoel Kashman

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Image Persented A novel nitrogenous bismacrolide, designated tausalarin C (1), was isolated from the Madagascar sponge Fascaplysinopsis sp. The structure of the compound was elucidated by interpretation of MS and 1D and 2D NMR spectra. It is suggested that tausalarin C is assembled from salarin A (2) and pretaumycin A. The relative configuration of the chiral centers of salarin A was determined by X-ray diffraction. Tausalarin C was found to inhibit proliferation of K562 leukemia cells. A possible biogenesis is discussed.

Original language	English
Pages (from-to)	3538-3541
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	16
DOIs	https://doi.org/10.1021/ol9011019
State	Published - 20 Aug 2009

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10.1021/ol9011019

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title = "Tausalarin C: A new bioactive marine sponge-derived nitrogenous bismacrolide",

abstract = "Image Persented A novel nitrogenous bismacrolide, designated tausalarin C (1), was isolated from the Madagascar sponge Fascaplysinopsis sp. The structure of the compound was elucidated by interpretation of MS and 1D and 2D NMR spectra. It is suggested that tausalarin C is assembled from salarin A (2) and pretaumycin A. The relative configuration of the chiral centers of salarin A was determined by X-ray diffraction. Tausalarin C was found to inhibit proliferation of K562 leukemia cells. A possible biogenesis is discussed.",

author = "Ashgan Bishara and Amira Rudi and Israel Goldberg and Maurice Aknin and Drorit Neumann and Nathalie Ben-Califa and Yoel Kashman",

year = "2009",

month = aug,

day = "20",

doi = "10.1021/ol9011019",

language = "אנגלית",

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T2 - A new bioactive marine sponge-derived nitrogenous bismacrolide

AU - Bishara, Ashgan

AU - Rudi, Amira

AU - Goldberg, Israel

AU - Aknin, Maurice

AU - Neumann, Drorit

AU - Ben-Califa, Nathalie

AU - Kashman, Yoel

PY - 2009/8/20

Y1 - 2009/8/20

N2 - Image Persented A novel nitrogenous bismacrolide, designated tausalarin C (1), was isolated from the Madagascar sponge Fascaplysinopsis sp. The structure of the compound was elucidated by interpretation of MS and 1D and 2D NMR spectra. It is suggested that tausalarin C is assembled from salarin A (2) and pretaumycin A. The relative configuration of the chiral centers of salarin A was determined by X-ray diffraction. Tausalarin C was found to inhibit proliferation of K562 leukemia cells. A possible biogenesis is discussed.

AB - Image Persented A novel nitrogenous bismacrolide, designated tausalarin C (1), was isolated from the Madagascar sponge Fascaplysinopsis sp. The structure of the compound was elucidated by interpretation of MS and 1D and 2D NMR spectra. It is suggested that tausalarin C is assembled from salarin A (2) and pretaumycin A. The relative configuration of the chiral centers of salarin A was determined by X-ray diffraction. Tausalarin C was found to inhibit proliferation of K562 leukemia cells. A possible biogenesis is discussed.

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SN - 1523-7060

VL - 11

SP - 3538

EP - 3541

JO - Organic Letters

JF - Organic Letters

IS - 16

ER -

Tausalarin C: A new bioactive marine sponge-derived nitrogenous bismacrolide

Abstract

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