Taumycins a and B, Two bioactive lipodepsipeptides from the Madagascar sponge Fascaplysinopsis sp

Ashgan Bishara; Amira Rudi; Maurice Aknin; Drorit Neumann; Nathalie Ben-Califa; Yoel Kashman

doi:10.1021/ol801750y

Taumycins a and B, Two bioactive lipodepsipeptides from the Madagascar sponge Fascaplysinopsis sp

Ashgan Bishara^*, Amira Rudi, Maurice Aknin, Drorit Neumann, Nathalie Ben-Califa, Yoel Kashman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

(Chemical Equation Presented) Two closely related lipodepsipeptides, taumycins A and B (1 and 2) have been isolated from the Madagascar sponge Fascaplysinopsis sp. The two compounds have the same 12-membered oxodepsipeptide ring system in common. Both were toxic to brine shrimp larvae, and taumycin A (1 μM), but not taumycin B, inhibited growth of the human UT-7 leukemic cell line. The structure of the two compounds, likely to be derived from microorganisms, was established by MS and 1D and 2D NMR data.

Original language	English
Pages (from-to)	4307-4309
Number of pages	3
Journal	Organic Letters
Volume	10
Issue number	19
DOIs	https://doi.org/10.1021/ol801750y
State	Published - 2008

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abstract = "(Chemical Equation Presented) Two closely related lipodepsipeptides, taumycins A and B (1 and 2) have been isolated from the Madagascar sponge Fascaplysinopsis sp. The two compounds have the same 12-membered oxodepsipeptide ring system in common. Both were toxic to brine shrimp larvae, and taumycin A (1 μM), but not taumycin B, inhibited growth of the human UT-7 leukemic cell line. The structure of the two compounds, likely to be derived from microorganisms, was established by MS and 1D and 2D NMR data.",

author = "Ashgan Bishara and Amira Rudi and Maurice Aknin and Drorit Neumann and Nathalie Ben-Califa and Yoel Kashman",

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AU - Bishara, Ashgan

AU - Rudi, Amira

AU - Aknin, Maurice

AU - Neumann, Drorit

AU - Ben-Califa, Nathalie

AU - Kashman, Yoel

PY - 2008

Y1 - 2008

N2 - (Chemical Equation Presented) Two closely related lipodepsipeptides, taumycins A and B (1 and 2) have been isolated from the Madagascar sponge Fascaplysinopsis sp. The two compounds have the same 12-membered oxodepsipeptide ring system in common. Both were toxic to brine shrimp larvae, and taumycin A (1 μM), but not taumycin B, inhibited growth of the human UT-7 leukemic cell line. The structure of the two compounds, likely to be derived from microorganisms, was established by MS and 1D and 2D NMR data.

AB - (Chemical Equation Presented) Two closely related lipodepsipeptides, taumycins A and B (1 and 2) have been isolated from the Madagascar sponge Fascaplysinopsis sp. The two compounds have the same 12-membered oxodepsipeptide ring system in common. Both were toxic to brine shrimp larvae, and taumycin A (1 μM), but not taumycin B, inhibited growth of the human UT-7 leukemic cell line. The structure of the two compounds, likely to be derived from microorganisms, was established by MS and 1D and 2D NMR data.

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ER -

Taumycins a and B, Two bioactive lipodepsipeptides from the Madagascar sponge Fascaplysinopsis sp

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