Taumycins a and B, Two bioactive lipodepsipeptides from the Madagascar sponge Fascaplysinopsis sp

Ashgan Bishara, Amira Rudi, Maurice Aknin, Drorit Neumann, Nathalie Ben-Califa, Yoel Kashman

Research output: Contribution to journalArticlepeer-review

Abstract

(Chemical Equation Presented) Two closely related lipodepsipeptides, taumycins A and B (1 and 2) have been isolated from the Madagascar sponge Fascaplysinopsis sp. The two compounds have the same 12-membered oxodepsipeptide ring system in common. Both were toxic to brine shrimp larvae, and taumycin A (1 μM), but not taumycin B, inhibited growth of the human UT-7 leukemic cell line. The structure of the two compounds, likely to be derived from microorganisms, was established by MS and 1D and 2D NMR data.

Original languageEnglish
Pages (from-to)4307-4309
Number of pages3
JournalOrganic Letters
Volume10
Issue number19
DOIs
StatePublished - 2008

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