Tachykinin modulation of coronary blood flow

David Ezra, Francisco R.M. Laurindo, Jacob Eimerl, Robert E. Goldstein, Carl C. Peck, Giora Feuerstein

Research output: Contribution to journalArticlepeer-review

Abstract

In pentobarbital anesthetized, open chest pigs, coronary blood flow (CBF), myocardial contractility and systemic hemodynamic variables were monitored during intracoronary injections of substance P (SP), neurokinin A (NA) or neurokinin B (NB). SP was most potent in increasing CBF although NA was also active in high doses while NB had absolutely no effect. SP was also more potent than NA in producing systemic hypotension. The data suggests that SP and its receptors might be potentially important modulators of CBF.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalEuropean Journal of Pharmacology
Volume122
Issue number1
DOIs
StatePublished - 11 Mar 1986
Externally publishedYes

Keywords

  • Coronary blood flow
  • Neurokinin A
  • Neurokinin B
  • Neuropeptides
  • Substance P
  • Tachykinins

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