TY - GEN
T1 - T 1 mapping, AIF and pharmacokinetic parameter extraction from dynamic contrast enhancement MRI data
AU - Liberman, Gilad
AU - Louzoun, Yoram
AU - Colliot, Olivier
AU - Ben Bashat, Dafna
PY - 2011
Y1 - 2011
N2 - Dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) is a sensitive, noninvasive technique for the assessment of microvascular properties of the tissue. Quantitative physiological parameters can be obtained using pharmacokinetic (PK) models that track contrast agents as it passes through the tissue vasculature. Such analysis usually requires prior knowledge of the voxels' T 1 values and of the Arterial Input Function (AIF). Therefore, relaxometry T 1 measurements are usually performed prior to contrast-agent injection and the AIF is manually or automatically extracted from the dynamic data. In this study, a method for a fully automatic analysis of DCE data for joint PK parameters, T 1 mapping and AIF extraction is proposed. Results are shown on simulated data compared to other methods and on data acquired from healthy subjects and patients with Glioblastoma who received anti-angiogenic therapy. The proposed method renders DCE analysis to be robust and easily applicable.
AB - Dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) is a sensitive, noninvasive technique for the assessment of microvascular properties of the tissue. Quantitative physiological parameters can be obtained using pharmacokinetic (PK) models that track contrast agents as it passes through the tissue vasculature. Such analysis usually requires prior knowledge of the voxels' T 1 values and of the Arterial Input Function (AIF). Therefore, relaxometry T 1 measurements are usually performed prior to contrast-agent injection and the AIF is manually or automatically extracted from the dynamic data. In this study, a method for a fully automatic analysis of DCE data for joint PK parameters, T 1 mapping and AIF extraction is proposed. Results are shown on simulated data compared to other methods and on data acquired from healthy subjects and patients with Glioblastoma who received anti-angiogenic therapy. The proposed method renders DCE analysis to be robust and easily applicable.
UR - http://www.scopus.com/inward/record.url?scp=80053505563&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-24446-9_10
DO - 10.1007/978-3-642-24446-9_10
M3 - ???researchoutput.researchoutputtypes.contributiontobookanthology.conference???
AN - SCOPUS:80053505563
SN - 9783642244452
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 76
EP - 83
BT - Multimodal Brain Image Analysis - First International Workshop, MBIA 2011, Held in Conjunction with MICCAI 2011, Proceedings
T2 - 1st International Workshop on Multimodal Brain Image Analysis, MBIA 2011, in Conjunction with the 14th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2011
Y2 - 18 September 2011 through 18 September 2011
ER -